778546-51-3
778546-51-3
Chemical Structure
A-77636
- CAS No.: 778546-51-3
- Formula:C20H27NO3
- Molecular Weight:329.43
IUPAC Name: (1R,3S)-3-((3S,5S,7S)-adamantan-1-yl)-1-(aminomethyl)isochromane-5,6-diol
InChIKey: QLJOSZATCBCBDR-XZSXYRPISA-N
SMILES: NC[C@@H]1O[C@H](C2(C[C@@H]3C4)C[C@H](C3)C[C@H]4C2)CC5=C(O)C(O)=CC=C51
Biological Activity: A-77636 is an orally active, potent, selective and long-acting dopamine D1 receptor agonist (pEC50 = 8.13; EC50 = 1.1 nM). A-77636 shows the highest affinity (pKi = 7.40 ± 0.09; Ki = 39.8 nM) for the dopamine D1 receptor. A-77636 shows antiparkinsonian activity[1].
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A-77636 | A-77636 is an orally active, potent, selective and long-acting dopamine D1 receptor agonist (pEC50 = 8.13; EC50 = 1.1 nM). A-77636 shows the highest affinity (pKi = 7.40 ± 0.09; Ki = 39.8 nM) for the dopamine D1 receptor. A-77636 shows antiparkinsonian activity. | |||||||||||||||||||||
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