78273-80-0
Chemical Structure
Roxatidine
- CAS No.: 78273-80-0
- Formula:C17H26N2O3
- Molecular Weight:306.41
IUPAC Name: 2-hydroxy-N-(3-(3-(piperidin-1-ylmethyl)phenoxy)propyl)acetamide
InChIKey: BCCREUFCSIMJFS-UHFFFAOYSA-N
SMILES: O=C(NCCCOC1=CC=CC(CN2CCCCC2)=C1)CO
Biological Activity: Roxatidine is an active metabolite of Roxatidine acetate hydrochloride, is an orally active histamine H2-receptor antagonist. Roxatidine, an anti-ulcer agent, suppresses histamine release (thus inhibiting proton secretion) and inhibits the production of VEGF-1, an important marker of inflammation and angiogenesis. Anti-allergic inflammatory effect. Roxatidine is promising for research of gastric and duodenal ulcers[1][2][3].
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Roxatidine | 98.25% | Roxatidine is an active metabolite of Roxatidine acetate hydrochloride, is an orally active histamine H2-receptor antagonist. Roxatidine, an anti-ulcer agent, suppresses histamine release (thus inhibiting proton secretion) and inhibits the production of VEGF-1, an important marker of inflammation and angiogenesis. Anti-allergic inflammatory effect. Roxatidine is promising for research of gastric and duodenal ulcers. | ||||||||||||||||||||
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Roxatidine (Standard) | ≥98% | Roxatidine (Standard) is the analytical standard of Roxatidine. This product is intended for research and analytical applications. Roxatidine is an active metabolite of Roxatidine acetate hydrochloride, is a histamine H2-receptor antagonist. Roxatidine, an anti-ulcer agent, suppresses histamine release (thus inhibiting proton secretion) and inhibits the production of VEGF-1, an important marker of inflammation and angiogenesis. Anti-allergic inflammatory effect. | ||||||||||||||||||||
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Roxatidine-d10 hemioxalate | Roxatidine-d10 (hemioxalate) is the deuterium labeled Roxatidine hemioxalate. | |||||||||||||||||||||
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Similarity Score 0.98
HY-169223Roxatidine hydrochloride -
Similarity Score 0.88
HY-116208Dalcotidine -
Similarity Score 0.85
HY-116596Histamine H2 receptor antagonist-1 -
Similarity Score 0.84
HY-B0305Roxatidine acetate -
Similarity Score 0.84
HY-B0305ARoxatidine Acetate Hydrochloride -
Similarity Score 0.70
HY-12190JNJ-5207852 -
Similarity Score 0.68
HY-19010BMY-25368 -
Similarity Score 0.68
HY-B0364ADyclonine hydrochloride -
Similarity Score 0.67
HY-19010ABMY-25368 hydrochloride -
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References
- [1]. Lee M, et al. Roxatidine attenuates mast cell-mediated allergic inflammation via inhibition of NF-κB and p38 MAPK activation. Sci Rep. 2017;7:41721. Published 2017 Jan 31. [Content Brief]
- [2]. Collins JD, et al. Pharmacokinetics of roxatidine in healthy volunteers. Drugs. 1988;35 Suppl 3:41-7. [Content Brief]
- [3]. Cho EJ, et al. Roxatidine suppresses inflammatory responses via inhibition of NF-κB and p38 MAPK activation in LPS-induced RAW 264.7 macrophages. J Cell Biochem. 2011 Dec;112(12):3648-59. [Content Brief]
