78613-35-1
78613-35-1
Chemical Structure
Amorolfine
Synonym(s): Ro 14-4767; Ro 14-4767/000
- CAS. Nr.: 78613-35-1
- Formula:C21H35NO
- Molecular Weight:317.51
IUPAC Name: (2R,6S)-2,6-dimethyl-4-(2-methyl-3-(4-(tert-pentyl)phenyl)propyl)morpholine
InChIKey: MQHLMHIZUIDKOO-AYHJJNSGSA-N
SMILES: C[C@H]1O[C@H](CN(C1)CC(CC2=CC=C(C=C2)C(C)(CC)C)C)C
Biological Activity: Amorolfine (Ro 14-4767) is an antifungal agent. Amorolfine ameliorates the onychomycosis through inhibition of ergosterol biosynthesis. Amorolfine inhibits Candida albicans with a MIC of 0.404 µg/mL[1][2].
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Amorolfine | Amorolfine (Ro 14-4767) is an antifungal agent. Amorolfine ameliorates the onychomycosis through inhibition of ergosterol biosynthesis. Amorolfine inhibits Candida albicans with a MIC of 0.404 µg/mL. | |||||||||||||||||||||
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References
- [1]. Pittrof F, et al., Loceryl nail lacquer--realization of a new galenical approach to onychomycosis therapy. Clin Exp Dermatol. 1992 Sep;17 Suppl 1:26-8. [Content Brief]
- [2]. Haria M, et al. Amorolfine. A review of its pharmacological properties and therapeutic potential in the treatment of onychomycosis and other superficial fungal infections. Drugs. 1995 Jan;49(1):103-20. [Content Brief]
