79-50-5
79-50-5
Chemical Structure
DL-Pantolactone
- CAS No.: 79-50-5
- Formula:C6H10O3
- Molecular Weight:130.14
IUPAC Name: 3-hydroxy-4,4-dimethyldihydrofuran-2(3H)-one
InChIKey: SERHXTVXHNVDKA-UHFFFAOYSA-N
SMILES: O=C1OCC(C)(C)C1O
Biological Activity: DL-Pantolactone is a γ-lactone that can be hydrolyzed to Pantoic acid (HY-W399035) by the lactonohydrolase of Fusarium oxysporum. DL-Pantolactone also can be used in the preparation of 3,5-dinitrobenzoyl-DL-pantolactone[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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DL-Pantolactone | 99.30% | DL-Pantolactone is a γ-lactone that can be hydrolyzed to Pantoic acid (HY-W399035) by the lactonohydrolase of Fusarium oxysporum. DL-Pantolactone also can be used in the preparation of 3,5-dinitrobenzoyl-DL-pantolactone. | ||||||||||||||||||||
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DL-Pantolactone (Standard) | ≥98% | DL-Pantolactone (Standard) is the analytical standard of DL-Pantolactone (HY-W053519). This product is intended for research and analytical applications. DL-Pantolactone is a γ-lactone that can be hydrolyzed to Pantoic acid (HY-W399035) by the lactonohydrolase of Fusarium oxysporum. DL-Pantolactone also can be used in the preparation of 3,5-dinitrobenzoyl-DL-pantolactone. | ||||||||||||||||||||
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DL-Mevalonolactone | 99.25% | DL-Mevalonolactone ((±)-Mevalonolactone;Mevalolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone is orally active against HMGCR mutation and statin caused myopathy. DL-Mevalonolactone induces inflammation and oxidative stress response with decreased mitochondrial membrane potential (MMP) and induces mitochondrial swelling. | ||||||||||||||||||||
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DL-Mevalonolactone-13C | DL-Mevalonolactone-13C ((±)-Mevalonolactone-13C) is the 13C-labeled DL-Mevalonolactone (HY-107855). DL-Mevalonolactone ((±)-Mevalonolactone;Mevalolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone is orally active against HMGCR mutation and statin caused myopathy. DL-Mevalonolactone induces inflammation and oxidative stress response with decreased mitochondrial membrane potential (MMP) and induces mitochondrial swelling. | |||||||||||||||||||||
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DL-Mevalonolactone-13C2 | DL-Mevalonolactone-13C2 ((±)-Mevalonolactone-13C2) is the 13C-labeled DL-Mevalonolactone (HY-107855). DL-Mevalonolactone ((±)-Mevalonolactone;Mevalolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone is orally active against HMGCR mutation and statin caused myopathy. DL-Mevalonolactone induces inflammation and oxidative stress response with decreased mitochondrial membrane potential (MMP) and induces mitochondrial swelling. | |||||||||||||||||||||
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Mevalonolactone | 98.0% | Mevalonolactone is an intermediate metabolite in the eukaryotic mevalonate pathway, serving as the stable δ-lactone form of mevalonate with oral activity. Mevalonolactone exhibits binding affinity for ZNF384 (Ka = 12.6 μM) and inhibitory activity against aconitase (aconitase). Mevalonolactone promotes the nuclear localization of ZNF384 and enhances its binding to the GGPPS promoter. Mevalonolactone induces insulin resistance, disrupts glucose and lipid metabolism, enhances the isoprenylation of K-Ras, and inhibits the activation of the insulin signaling pathway. Mevalonolactone inhibits polypeptide synthesis of HMG-CoA reductase in isolated rat hepatocytes, promotes its degradation, and reduces its enzymatic activity. Mevalonolactone impairs mitochondrial function in rat brains. Mevalonolactone promotes the development of metabolically unhealthy obesity. Mevalonolactone can be used in research related to metabolically abnormal obesity, mevalonic aciduria, HMGCR-related limb-girdle myopathy, and statin-induced myopathy. | ||||||||||||||||||||
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(–)-Erythro-saccharinic acid lactone | (–)-Erythro-saccharinic acid lactone (compound2) can be isolated from the leaves of Talauma arcabucoana. | |||||||||||||||||||||
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(1S)-Chrysanthemolactone | (1S)-Chrysanthemolactone is a Monoterpenoids product that can be isolated from the flowers of Dendranthema indicum. | |||||||||||||||||||||
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(1R)-Chrysanthemolactone | (1R)-Chrysanthemolactone is a Monoterpenoids product that can be isolated from the flowers of Dendranthema indicum. | |||||||||||||||||||||
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D-(-)-Pantolactone | 99.96% | D-(-)-Pantolactone is an important intermediate that can be used in the synthesis of other active compounds, such as the molluscicide Cyanolide A. D-(-)-Pantolactone is also a calibrant for circular dichroism (CD). | ||||||||||||||||||||
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L-Threonolactone | 98.0% | L-Threonolactone ((3R,4S)-3,4-Dihydroxyoxolan-2-one) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. | ||||||||||||||||||||
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Sacubitrilat impurity 32 | 99.96% | Sacubitrilat impurity 32 is an impurity of Sacubitrilat (HY-17620). | ||||||||||||||||||||
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References
- [1]. Goodhue CT, et, al. The bacterial degradation of pantothenic acid. 3. Enzymatic formation of aldopantoic acid. Biochemistry. 1966 Feb;5(2):403-8. [Content Brief]
- [2]. Shimizu S, et, al. Optical resolution of pantolactone by a novel fungal enzyme, lactonohydrolase. Ann N Y Acad Sci. 1996 Oct 12;799:650-8. [Content Brief]
