793671-47-3
Chemical Structure
8-Chloro-ATP tetrasodium
- CAS No.: 793671-47-3
- Formula:C10H11ClN5Na4O13P3
- Molecular Weight:629.55
IUPAC Name: sodium ((2R,3S,4R,5R)-5-(6-amino-8-chloro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl triphosphate
InChIKey: BIFUJGGPLKGBNZ-ZVQJTLEUSA-J
SMILES: NC1=NC=NC2=C1N=C(Cl)N2[C@H]3[C@H](O)[C@H](O)[C@@H](COP(OP(OP(O[Na])(O[Na])=O)(O[Na])=O)(O[Na])=O)O3
Biological Activity: 8-Chloro-ATP tetrasodium, an ATP (HY-B2176) analog, is a topoisomerase II (Topo II) inhibitor. 8-Chloro-ATP tetrasodium inhibits DNA synthesis and induces DNA double-stranded breaks (DSBs). 8-Chloro-ATP tetrasodium inhibits Topo II-catalyzed ATP hydrolysis[1].
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8-Chloro-ATP tetrasodium | 8-Chloro-ATP tetrasodium, an ATP (HY-B2176) analog, is a topoisomerase II (Topo II) inhibitor. 8-Chloro-ATP tetrasodium inhibits DNA synthesis and induces DNA double-stranded breaks (DSBs). 8-Chloro-ATP tetrasodium inhibits Topo II-catalyzed ATP hydrolysis. | |||||||||||||||||||||
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Keywords
