825651-66-9
Chemical Structure
TAMRA azide, 5-isomer
- CAS No.: 825651-66-9
- Formula:C28H28N6O4
- Molecular Weight:512.56
IUPAC Name: (2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluorotetrahydrofuran-3-yl benzoate
InChIKey: XASWYZOPZJEQFF-UHFFFAOYSA-N
SMILES: [N-]=[N+]=NCCCNC(C1=CC(C([O-])=O)=C(C2=C3C=CC(N(C)C)=CC3=[O+]C4=C2C=CC(N(C)C)=C4)C=C1)=O
Biological Activity: TAMRA azide, 5-isomer is a click chemical containing azide groups that can be used as a linker for TAMRA. The azide group of TAMRA Azide, 5-isomer enables copper-catalyzed click chemical reactions with alkynes, DBCO, and BCN[1][2]. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups (Ex/Em = 555/580 nm).
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TAMRA azide, 5-isomer | 98.60% | TAMRA azide, 5-isomer is a click chemical containing azide groups that can be used as a linker for TAMRA. The azide group of TAMRA Azide, 5-isomer enables copper-catalyzed click chemical reactions with alkynes, DBCO, and BCN. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups (Ex/Em = 555/580 nm). | ||||||||||||||||||||
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- [1]. Willnow S, et al. A selenium-based click AdoMet analogue for versatile substrate labeling with wild-type protein methyltransferases. Chembiochem. 2012 May 29;13(8):1167-73. [Content Brief]
- [2]. Jiang X, et al. Recent applications of click chemistry in drug discovery. Expert Opin Drug Discov. 2019 Aug;14(8):779-789. [Content Brief]
Keywords
