847249-57-4
847249-57-4
Chemical Structure
AES-350
- CAS No.: 847249-57-4
- Formula:C18H20N2O3
- Molecular Weight:312.36
IUPAC Name: 4-(tert-butyl)-N-(4-(hydroxycarbamoyl)phenyl)benzamide
InChIKey: FMOQHLZNJFXULZ-UHFFFAOYSA-N
SMILES: O=C(NO)C1=CC=C(NC(C2=CC=C(C(C)(C)C)C=C2)=O)C=C1
Biological Activity: AES-350 is a potent and orally active HDAC6 inhibitor with an IC50 and a Ki of 0.0244 μM and 0.035 μM, respectively. AES-350 is also against HDAC3, HDAC8 in an enzymatic activity assay with IC50 values of 0.187 μM and 0.245 μM, respectively. AES-350 triggers apoptosis in AML cells through HDAC inhibition and can be used for acute myeloid leukemia (AML) research[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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AES-350 | 99.30% | AES-350 is a potent and orally active HDAC6 inhibitor with an IC50 and a Ki of 0.0244 μM and 0.035 μM, respectively. AES-350 is also against HDAC3, HDAC8 in an enzymatic activity assay with IC50 values of 0.187 μM and 0.245 μM, respectively. AES-350 triggers apoptosis in AML cells through HDAC inhibition and can be used for acute myeloid leukemia (AML) research. | ||||||||||||||||||||
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