87099-85-2
Chemical Structure
Spicamycin
- CAS. Nr.: 87099-85-2
- Formula:C30H51N7O7
- Molecular Weight:621.77
IUPAC Name: N-(2-(((2R,3R,4R,5R,6S)-6-((7H-purin-6-yl)amino)-2-((S)-1,2-dihydroxyethyl)-4,5-dihydroxytetrahydro-2H-pyran-3-yl)amino)-2-oxoethyl)-14-methylpentadecanamide
InChIKey: YBZRLMLGUBIIDN-DUSHZQPUSA-N
SMILES: OC[C@H](O)[C@]([C@H](NC(CNC(CCCCCCCCCCCCC(C)C)=O)=O)[C@@H](O)[C@H]1O)([H])O[C@@H]1NC2=C3C(N=CN3)=NC=N2
Biological Activity: Spicamycin, an adenine nucleoside antibiotic with antifungal and antitumor activities. Spicamycin is also a potent inducer of differentiation of myeloid leukemia cells. Spicamycin induces apoptosis in NB4 cells via down-regulation of Bcl-2 expression and modulation of PML protein[1][2].
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Spicamycin | Spicamycin, an adenine nucleoside antibiotic with antifungal and antitumor activities. Spicamycin is also a potent inducer of differentiation of myeloid leukemia cells. Spicamycin induces apoptosis in NB4 cells via down-regulation of Bcl-2 expression and modulation of PML protein. | |||||||||||||||||||||
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References
- [1]. Zhang WJ, et al. Spicamycin and KRN5500 induce apoptosis in myeloid and lymphoid cell lines with down-regulation of bcl-2 expression and modulation of promyelocytic leukemia protein. Jpn J Cancer Res. 2000 Jun;91(6):604-11. [Content Brief]
- [2]. Hayakawa Y, et al. Spicamycin, a new differentiation inducer of mouse myeloid leukemia cells (Ml) and human promyelocytic leukemia cells (HL-60)[J]. Agricultural and biological chemistry, 1985, 49(9): 2685-2691.
