871814-52-7

Libvatrep Chemical Structure
871814-52-7

Chemical Structure

Libvatrep

Synonym(s): SAF312; Vanilloid receptor antagonist 1

  • CAS No.: 871814-52-7
  • Formula:C18H15N3O2
  • Molecular Weight:305.33

IUPAC Name: 4-(7-hydroxy-2-isopropyl-4-oxoquinazolin-3(4H)-yl)benzonitrile

InChIKey: JFPXRFIBKKSHGY-UHFFFAOYSA-N

SMILES: N#CC1=CC=C(N2C(C(C)C)=NC3=C(C=CC(O)=C3)C2=O)C=C1

Biological Activity: Libvatrep (SAF312) is a non-competitive TRPV1 antagonist with an IC50 of 0.35-0.69 µM in HEK293T cells. It binds to the vanilloid pocket and an allosteric site, preventing S4/S5 conformational changes and channel opening. Libvatrep can be used for research on ocular surface pain and eye pain after photorefractive keratectomy[1][2][3][4].

Cat. No. Product Name Purity Description Pricing
HY-114017 		Libvatrep 99.54% Libvatrep (SAF312) is a non-competitive TRPV1 antagonist with an IC50 of 0.35-0.69 µM in HEK293T cells. It binds to the vanilloid pocket and an allosteric site, preventing S4/S5 conformational changes and channel opening. Libvatrep can be used for research on ocular surface pain and eye pain after photorefractive keratectomy.
Pricing 
Expand Hide
loading...
/
  • /
loading...
Size Price
Stock Quantity Availability Operate
/
In-stock
(Estimated to ship on )
(Estimated to ship TODAY)
Estimated to ship on
(Estimated to ship TODAY)

Amount:

USD 0.00

This product is a controlled substance and not for sale in your territory.

This product is not for sale in your territory.

This compound is listed in the SVHC (Substances of Very High Concern) candidate list of ECHA (European Chemicals Agency).

Pricing 
Expand Hide
Structural Analogs

References

Keywords