873315-86-7
Chemical Structure
MitoTracker Deep Red FM
Synonym(s): MTDR FM
- CAS No.: 873315-86-7
- Formula:C34H36Cl2N2
- Molecular Weight:543.57
IUPAC Name: 2-((1E,3E)-5-((Z)-1-(4-(chloromethyl)benzyl)-3,3-dimethylindolin-2-ylidene)penta-1,3-dien-1-yl)-1,3,3-trimethyl-3H-indol-1-ium chloride
InChIKey: IRSFLEQGOMAAPU-UHFFFAOYSA-M
SMILES: ClCC1=CC=C(CN2C3=C(C(C)(C)/C2=C/C=C/C=C/C4=[N+](C)C5=C(C4(C)C)C=CC=C5)C=CC=C3)C=C1.[Cl-]
Biological Activity:
MitoTracker Deep Red (MTDR) FM fluorescent dye that selectively accumulates in the mitochondrial matrix. MitoTracker Deep Red FM covalently binds mitochondrial proteins by reacting with free mercaptan of cysteine residues, allowing staining of mitochondrial membrane potential independent of membrane potential. Excitation/emission wavelength 644/665 nm[1]. MitoTracker Deep Red dyes have an excitation/emission wavelength of 633/650-750 nm[2].
The Ex/Em of MitoTracker Deep Red (MTDR) FM is 644/665 nm.
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MitoTracker Deep Red FM | 98.01% | MitoTracker Deep Red (MTDR) FM fluorescent dye that selectively accumulates in the mitochondrial matrix. MitoTracker Deep Red FM covalently binds mitochondrial proteins by reacting with free mercaptan of cysteine residues, allowing staining of mitochondrial membrane potential independent of membrane potential. Excitation/emission wavelength 644/665 nm. MitoTracker Deep Red dyes have an excitation/emission wavelength of 633/650-750 nm. The Ex/Em of MitoTracker Deep Red (MTDR) FM is 644/665 nm. |
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MitoTracker Deep Red FM (solution) | MitoTracker Deep Red FM (solution) (MTDR FM (solution)) selectively accumulates in the mitochondrial matrix. MitoTracker Deep Red FM covalently binds mitochondrial proteins by reacting with free mercaptan of cysteine residues, allowing staining of mitochondrial membrane potential independent of membrane potential. The Ex/Em of MitoTracker Deep Red (MTDR) FM is 644/665 nm. Solvent and concentration: DMSO: 1 mM |
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- [1]. Buckman JF, et al. MitoTracker labeling in primary neuronal and astrocytic cultures: influence of mitochondrial membrane potential and oxidants. J Neurosci Methods. 2001 Jan 15;104(2):165-76. [Content Brief]
- [2]. Wang FX, et al. Mitochondria-Accumulating Rhenium(I) Tricarbonyl Complexes Induce Cell Death via Irreversible Oxidative Stress and Glutathione Metabolism Disturbance. ACS Appl Mater Interfaces. 2019 Apr 10;11(14):13123-13133. [Content Brief]
