876625-29-5
Chemical Structure
S07-1066
- CAS No.: 876625-29-5
- Formula:C16H11Cl2FO2
- Molecular Weight:325.16
InChIKey: DFJGLZRYGZSQOR-UHFFFAOYSA-N
SMILES: ClC1=CC(Cl)=CC(C2=CC=C(C3(C(O)=O)CC3)C=C2F)=C1
Biological Activity: S07-1066 is an aldo-keto reductase 1C3 (AKR1C3) inhibitor, synergizing doxorubicin (DOX) cytotoxicity. S07-1066 selectively blocks AKR1C3-mediated reduction of DOX, and reverses the DOX resistance in overexpressing AKR1C3 cells[1].
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S07-1066 | 99.48% | S07-1066 is an aldo-keto reductase 1C3 (AKR1C3) inhibitor, synergizing doxorubicin (DOX) cytotoxicity. S07-1066 selectively blocks AKR1C3-mediated reduction of DOX, and reverses the DOX resistance in overexpressing AKR1C3 cells. | ||||||||||||||||||||
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Keywords