88980-20-5
Chemical Structure
Mexiprostil
Synonym(s): MDL 646
- No. CAS: 88980-20-5
- Formula:C23H40O6
- Molecular Weight:412.56
IUPAC Name: methyl 7-((1R,2R,3R)-3-hydroxy-2-((3R,E)-3-hydroxy-4-methoxy-4-methyloct-1-en-1-yl)-5-oxocyclopentyl)heptanoate
InChIKey: GGDWDKDPRJFMHD-ZXYUVVQBSA-N
SMILES: CCCCC(OC)(C)[C@H](O)/C=C/[C@@H]1[C@H](C(C[C@H]1O)=O)CCCCCCC(OC)=O
Biological Activity: Mexiprostil (MDL 646) is an orally active gastric protectant, being a synthetic analogue of Prostaglandin E1 (HY-B0131). Mexiprostil exhibits significant inhibition of gastric acid secretion caused by Histamine (HY-B1204) and Bethanechol (HY-B0406) in rats, dogs, and cats. Mexiprostil can also inhibit the increase in gastric acid secretion caused by Pentagastrin (HY-A0261) in cats, while it does not have this effect in dogs and rats. Mexiprostil does not cause pregnancy termination. Mexiprostil can be used for research on gastric ulcers[1][2].
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Mexiprostil | Mexiprostil (MDL 646) is an orally active gastric protectant, being a synthetic analogue of Prostaglandin E1 (HY-B0131). Mexiprostil exhibits significant inhibition of gastric acid secretion caused by Histamine (HY-B1204) and Bethanechol (HY-B0406) in rats, dogs, and cats. Mexiprostil can also inhibit the increase in gastric acid secretion caused by Pentagastrin (HY-A0261) in cats, while it does not have this effect in dogs and rats. Mexiprostil does not cause pregnancy termination. Mexiprostil can be used for research on gastric ulcers. | |||||||||||||||||||||
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References
- [1]. Müller P, et al. An alprostadil analogue and human gastric secretion. A double-blind placebo-controlled study of the effects of a capsule and tablet formulation. Arzneimittelforschung. 1989 Jul;39(7):809-11. [Content Brief]
- [2]. Scarpignato C, et al. Action of MDL 646, a new synthetic prostaglandin, on gastric acid secretion of some experimental animals. Res Commun Chem Pathol Pharmacol. 1983 Feb;39(2):211-28. [Content Brief]
