893426-86-3
Chemical Structure
AE9C90CB free base
- CAS No.: 893426-86-3
- Formula:C21H24N2O2
- Molecular Weight:336.44
IUPAC Name: N-(((1R,5S,6r)-3-azabicyclo[3.1.0]hexan-6-yl)methyl)-2-hydroxy-N-methyl-2,2-diphenylacetamide
InChIKey: AARSINSGAQDAKQ-BWTSREIZSA-N
SMILES: C(C(N(C[C@@H]1[C@@]2([C@]1(CNC2)[H])[H])C)=O)(O)(C3=CC=CC=C3)C4=CC=CC=C4
Biological Activity: AE9C90CB free base is an M3 muscarinic receptor (mAChR) antagonist and M2 muscarinic receptor ligand (human pKi values of 9.9 and 8.6, respectively). AE9C90CB binds to the M3 receptor and produces an insurmountable antagonism of Carbamoylcholine chloride (HY-B1208)-induced bladder strip contraction, thereby inhibiting the elevation of intravesical pressure and salivation, and exhibits functional selectivity for the bladder relative to the salivary glands. AE9C90CB can be used in the study of overactive bladder[1].
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AE9C90CB free base | AE9C90CB free base is an M3 muscarinic receptor (mAChR) antagonist and M2 muscarinic receptor ligand (human pKi values of 9.9 and 8.6, respectively). AE9C90CB binds to the M3 receptor and produces an insurmountable antagonism of Carbamoylcholine chloride (HY-B1208)-induced bladder strip contraction, thereby inhibiting the elevation of intravesical pressure and salivation, and exhibits functional selectivity for the bladder relative to the salivary glands. AE9C90CB can be used in the study of overactive bladder. | |||||||||||||||||||||
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