895519-90-1
895519-90-1
Chemical Structure
Flumatinib
Synonym(s): HHGV678
- CAS No.: 895519-90-1
- Formula:C29H29F3N8O
- Molecular Weight:562.59
IUPAC Name: N-(6-methyl-5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)pyridin-3-yl)-4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide
InChIKey: BJCJYEYYYGBROF-UHFFFAOYSA-N
SMILES: O=C(NC1=CC(NC2=NC=CC(C3=CC=CN=C3)=N2)=C(C)N=C1)C4=CC=C(CN5CCN(C)CC5)C(C(F)(F)F)=C4
Biological Activity: Flumatinib (HHGV678) is an orally available, selective inhibitor of Bcr-Abl. Flumatinib inhibits c-Abl, PDGFRβ and c-Kit with IC50s of 1.2 nM, 307.6 nM and 665.5 nM, respectively[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Flumatinib | 99.62% | Flumatinib (HHGV678) is an orally available, selective inhibitor of Bcr-Abl. Flumatinib inhibits c-Abl, PDGFRβ and c-Kit with IC50s of 1.2 nM, 307.6 nM and 665.5 nM, respectively. | ||||||||||||||||||||
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Flumatinib-d3 | 99.9% | Flumatinib-d3 is deuterium labeled Flumatinib. Flumatinib (HHGV678) is an orally available, selective inhibitor of Bcr-Abl. Flumatinib inhibits c-Abl, PDGFRβ and c-Kit with IC50s of 1.2 nM, 307.6 nM and 665.5 nM, respectively. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.94
HY-13905Flumatinib mesylate -
Similarity Score 0.69
HY-15463RImatinib (Standard) -
Similarity Score 0.69
HY-50868RBafetinib (Standard) -
Similarity Score 0.68
HY-50946Imatinib Mesylate -
Similarity Score 0.65
HY-111849Imatinib carbaldehyde -
Similarity Score 0.64
HY-15463S2Imatinib-d3 hydrochloride -
Similarity Score 0.64
HY-135638Imatinib Acid -
Similarity Score 0.64
HY-15463S1Imatinib-d4 -
Similarity Score 0.63
HY-G0017RN-Desmethyl imatinib (Standard) -
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