9061-57-8
Chemical Structure
Atelopidtoxin
- CAS No.: 9061-57-8
- Formula:C16H24N8O12S
- Molecular Weight:552.47
IUPAC Name: (S)-2-((3aS,3a1S,4'R,8R,9aS)-5,11-diamino-2,3',9,9-tetrahydroxy-2',3-dioxo-2,3,3a,3a1-tetrahydro-1H,7H,9H-spiro[pyrimido[1,6,5-gh]pyrrolo[1,2-c]purine-8,6'-[1,3]oxazinan]-4'-yl)-3-hydroxypropyl hydrogen sulfate
InChIKey: KRRJLHUVFILNLG-FKOGTDRGSA-N
SMILES: OC1([C@@]23[C@@]4([H])N(CN(C([C@@]4([H])N=C(N3C[C@]15C[C@](N(C(O5)=O)O)([H])[C@@H](CO)COS(=O)(O)=O)N)=O)O)C(N)=N2)O
Biological Activity: Atelopidtoxin (zetekitoxin) is a toxin (LD50=0.016 mg/kg for mice), which can be isolated from Panamanian frog Atelopus zeteki. Atelopidtoxin causes hypotension and ventricular fibrillation in rabbits. Atelopidtoxin an inhibitor for sodium channel[1][2].
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Atelopidtoxin | Atelopidtoxin (zetekitoxin) is a toxin (LD50=0.016 mg/kg for mice), which can be isolated from Panamanian frog Atelopus zeteki. Atelopidtoxin causes hypotension and ventricular fibrillation in rabbits. Atelopidtoxin an inhibitor for sodium channel. | |||||||||||||||||||||
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- [1]. Yotsu-Yamashita M, et al. The structure of zetekitoxin AB, a saxitoxin analog from the Panamanian golden frog Atelopus zeteki: a potent sodium-channel blocker. Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4346-51. [Content Brief]
- [2]. Shindelman J, et al., Atelopidtoxin from the Panamanian frog, Atelopus zeteki. Toxicon. 1969 Dec;7(4):315-9. [Content Brief]
Keywords
