92899-39-3
Chemical Structure
Chemotactic Domain of Elastin
- CAS No.: 92899-39-3
- Formula:C22H38N6O7
- Molecular Weight:498.57
InChIKey: RLCSROTYKMPBDL-USJZOSNVSA-N
SMILES: CC(C)[C@H](N)C(NCC(N[C@@H](C(C)C)C(N[C@@H](C)C(N1[C@@H](CCC1)C(NCC(O)=O)=O)=O)=O)=O)=O
Biological Activity: Chemotactic Domain of Elastin is an elastin-derived chemotactic hexapeptide that interacts with Galectin-3, integrin αvβ3, and elastin-binding protein (EBP) and promotes cell chemotaxis and migration. Chemotactic Domain of Elastin promotes melanoma cell migration by regulating invasion-related molecules such as CXCR-4/CXCL-12, MMP-2/MMP-3, cell adhesion molecules, and VEGF-C. Chemotactic Domain of Elastin is used for research on elastin-derived peptide signaling and tumor cell migration and invasion[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Chemotactic Domain of Elastin | 99.93% | Chemotactic Domain of Elastin is an elastin-derived chemotactic hexapeptide that interacts with Galectin-3, integrin αvβ3, and elastin-binding protein (EBP) and promotes cell chemotaxis and migration. Chemotactic Domain of Elastin promotes melanoma cell migration by regulating invasion-related molecules such as CXCR-4/CXCL-12, MMP-2/MMP-3, cell adhesion molecules, and VEGF-C. Chemotactic Domain of Elastin is used for research on elastin-derived peptide signaling and tumor cell migration and invasion. | ||||||||||||||||||||
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References
- [1]. Blood CH, et al. Identification of a tumor cell receptor for VGVAPG, an elastin-derived chemotactic peptide. The Journal of cell biology. 1988 Nov;107(5):1987-93. [Content Brief]
- [2]. Szychowski KA, et al. Impact of Elastin-Derived Peptide VGVAPG on Matrix Metalloprotease-2 and -9 and the Tissue Inhibitor of Metalloproteinase-1, -2, -3 and -4 mRNA Expression in Mouse Cortical Glial Cells In Vitro. Neurotoxicity research. 2019 Jan;35(1):100-110.
- [3]. Szychowski KA, et al. The VGVAPG Peptide Regulates the Production of Nitric Oxide Synthases and Reactive Oxygen Species in Mouse Astrocyte Cells In Vitro. Neurochemical research. 2019 May;44(5):1127-1137.
- [4]. Pocza P, et al. Locally generated VGVAPG and VAPG elastin-derived peptides amplify melanoma invasion via the galectin-3 receptor. International journal of cancer. 2008 May 01;122(9):1972-80.
