933768-63-9
Chemical Structure
INCB16562
- CAS No.: 933768-63-9
- Formula:C19H11Cl2N5
- Molecular Weight:380.23
IUPAC Name: 2-(2,6-dichlorophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b:4',3'-f]azepine
InChIKey: DVCPYUTZIIXGFE-UHFFFAOYSA-N
SMILES: ClC1=CC=CC(Cl)=C1C2=NC3=C(N2)C4=C(C=NC=C4)NC5=C3C=CC=N5
Biological Activity: INCB16562 is an orally active and selective inhibitor against JAK1/2 markedly selective over JAK3. INCB16562 potently inhibits interleukin-6 (IL-6)-induced phosphorylation of STAT3. Additionally, INCB16562 inhibits the proliferation and survival of myeloma cells dependent on IL-6 for growth, as well as the IL-6–induced growth of primary bone marrow-derived plasma cells. INCB16562 antagonizes the growth of myeloma xenografts in mice with antitumor activity. INCB16562 is promising for research of multiple myeloma[1].
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INCB16562 | INCB16562 is an orally active and selective inhibitor against JAK1/2 markedly selective over JAK3. INCB16562 potently inhibits interleukin-6 (IL-6)-induced phosphorylation of STAT3. Additionally, INCB16562 inhibits the proliferation and survival of myeloma cells dependent on IL-6 for growth, as well as the IL-6–induced growth of primary bone marrow-derived plasma cells. INCB16562 antagonizes the growth of myeloma xenografts in mice with antitumor activity. INCB16562 is promising for research of multiple myeloma. | |||||||||||||||||||||
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Keywords
