945490-09-5
Chemical Structure
Tomaymycin DM
- CAS No.: 945490-09-5
- Formula:C14H14N2O3
- Molecular Weight:258.27
IUPAC Name: (S)-8-hydroxy-7-methoxy-2-methylene-1,2,3,11a-tetrahydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-5-one
InChIKey: GXKVYHPROGIVCL-VIFPVBQESA-N
SMILES: O=C1N2[C@](CC(C2)=C)([H])C=NC3=CC(O)=C(OC)C=C13
Biological Activity:
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Tomaymycin DM | 95.73% | Tomaymycin DM is a derivative of Tomaymycin (HY-N10174) that belongs to the class of DNA alkylation inhibitors and acts as an effective payload for ADCs. Tomaymycin stabilizes the double-stranded DNA structure, inhibits various DNA processing enzymes, blocks transcription, and ultimately induces DNA strand breaks and apoptosis. Tomaymycin DM can be used in studies related to the development of ADCs targeting multiple cancers including leukemia and ovarian cancer. |
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- [1]. Foloppe MP, Rault S, Thurston DE, Jenkins TC, Robba M. DNA-binding properties of pyrrolo [2, 1-c][1, 4] benzodiazepine N10-C11 amidines. European journal of medicinal chemistry. 1996 Jan 1;31(5):407-10.
- [2]. Mantaj J, et al. From Anthramycin to Pyrrolobenzodiazepine (PBD)-Containing Antibody-Drug Conjugates (ADCs). Angew Chem Int Ed Engl. 2017;56(2):462-488. [Content Brief]
Keywords
