950980-98-0
Chemical Structure
PF-670462
- CAS No.: 950980-98-0
- Formula:C19H20FN5
- Molecular Weight:337.39
IUPAC Name: 4-(1-cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl)pyrimidin-2-amine
InChIKey: WUDBUIUHVNECTM-UHFFFAOYSA-N
SMILES: NC1=NC=CC(C2=C(C3=CC=C(F)C=C3)N=CN2C4CCCCC4)=N1
Biological Activity: PF-670462 is a selective CK1δ and CK1δε inhibitor (Ki of 10 nM and 50 nM, respectively). PF-670462 is also a ZDHHC8-specific inhibitor (Kd 15.9 μM). PF-670462 inhibits CK1-mediated LRRK2 phosphorylation. PF-670462 blocks PER phosphorylation and CK1δ/ε-dependent TGF-β signaling. PF-670462 reduces GPX4 palmitoylation, sensitizing tumor cells to Ferroptosis inducers. PF-670462 can be used for research on Parkinson's disease, NRAS-mutant melanoma, pulmonary fibrosis, chronic lymphocytic leukemia, diabetic nephropathy, and melanoma[1][2][3][4][5][6][7][8].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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PF-670462 | 99.24% | PF-670462 is a selective CK1δ and CK1δε inhibitor (Ki of 10 nM and 50 nM, respectively). PF-670462 is also a ZDHHC8-specific inhibitor (Kd 15.9 μM). PF-670462 inhibits CK1-mediated LRRK2 phosphorylation. PF-670462 blocks PER phosphorylation and CK1δ/ε-dependent TGF-β signaling. PF-670462 reduces GPX4 palmitoylation, sensitizing tumor cells to Ferroptosis inducers. PF-670462 can be used for research on Parkinson's disease, NRAS-mutant melanoma, pulmonary fibrosis, chronic lymphocytic leukemia, diabetic nephropathy, and melanoma. | ||||||||||||||||||||
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References
- [1]. De Wit T, et al. Inhibition of LRRK2 or Casein Kinase 1 Results in LRRK2 Protein Destabilization. Molecular neurobiology. 2019 Aug;56(8):5273-5286.
- [2]. Mahoney H, et al. Inhibition of casein kinase 1 δ/ε improves cognitive performance in adult C57BL/6J mice. Sci Rep. 2021 Feb 26;11(1):4746. [Content Brief]
- [3]. Zhang C, et al. Discovery and Synthesis of Selective Casein Kinase 1δ Degraders for Suppressing Oncogenic NRAS-Mutant Melanoma. Journal of Medicinal Chemistry.
- [4]. Keenan CR, et al. Casein kinase 1δ/ε inhibitor, PF670462 attenuates the fibrogenic effects of transforming growth factor-β in pulmonary fibrosis. Frontiers in pharmacology. 2018 Jul 10;9:738. [Content Brief]
- [5]. Chan P, et al. Watching the clock in glioblastoma. Neuro-oncology. 2023 Nov 02;25(11):1932-1946. [Content Brief]
- [6]. Park S. Identification of Potential Pharmacological Compounds to Promote Healthy Aging and Metabolic Health Through the Circadian Clock Using Neurospora crassa[D]. , 2023.
- [7]. Chen W, et al. ZDHHC8-mediated S-palmitoylation of RAD21 causes mitochondrial dysfunction in diabetic nephropathy via inhibiting ACSM3 transcription. Cell death and differentiation. 2026 Jul 15. [Content Brief]
- [8]. Zhou L, et al. Palmitoylation of GPX4 via the targetable ZDHHC8 determines ferroptosis sensitivity and antitumor immunity. Nature cancer. 2025 May;6(5):768-785. [Content Brief]
