99-05-8
Chemical Structure
3-Aminobenzoic acid
Synonym(s): m-Aminobenzoic acid; 3ABA
- CAS No.: 99-05-8
- Formula:C7H7NO2
- Molecular Weight:137.14
IUPAC Name: 3-aminobenzoic acid
InChIKey: XFDUHJPVQKIXHO-UHFFFAOYSA-N
SMILES: NC1=CC(C(O)=O)=CC=C1
Biological Activity: 3-Aminobenzoic acid (3-ABA) is an orally active anti-inflammatory agent targeting the tight junction (TJ) regulatory pathways in intestinal epithelial cells. 3-Aminobenzoic acid improves intestinal inflammation by enhancing intestinal barrier integrity and reducing epithelial permeability. It can be used in studies related to improving gut health. Additionally, 3-Aminobenzoic acid analogs can act as γ-aminobutyric acid transaminase (GABA-AT) inhibitors, exhibiting anticonvulsant effects[1][2][3][4].
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3-Aminobenzoic acid | 99.93% | 3-Aminobenzoic acid (3-ABA) is an orally active anti-inflammatory agent targeting the tight junction (TJ) regulatory pathways in intestinal epithelial cells. 3-Aminobenzoic acid improves intestinal inflammation by enhancing intestinal barrier integrity and reducing epithelial permeability. It can be used in studies related to improving gut health. Additionally, 3-Aminobenzoic acid analogs can act as γ-aminobutyric acid transaminase (GABA-AT) inhibitors, exhibiting anticonvulsant effects. | ||||||||||||||||||||
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3-Aminobenzoic acid (Standard) | ≥98% | 3-Aminobenzoic acid (Standard) is the analytical standard of 3-Aminobenzoic acid. This product is intended for research and analytical applications. 3-Aminobenzoic acid (3-ABA) is an orally active anti-inflammatory agent targeting the tight junction (TJ) regulatory pathways in intestinal epithelial cells. 3-Aminobenzoic acid improves intestinal inflammation by enhancing intestinal barrier integrity and reducing epithelial permeability. It can be used in studies related to improving gut health. Additionally, 3-Aminobenzoic acid analogs can act as γ-aminobutyric acid transaminase (GABA-AT) inhibitors, exhibiting anticonvulsant effects. | ||||||||||||||||||||
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3-Aminobenzoic acid-d4 | 3-Aminobenzoic acid-d4 is the deuterium labeled 3-Aminobenzoic acid. | |||||||||||||||||||||
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References
- [1]. Tanaka M, et al. Exploring 3-Aminobenzoic Acid as a Therapeutic Dietary Component for Enhancing Intestinal Barrier Integrity in Ulcerative Colitis[J]. bioRxiv, 2024: 2024.08. 18.608525.
- [2]. Tanaka M, et al. P095 Accelerated degradation of gut barrier-protecting 3-aminobenzoic acid exacerbate colitis in Inflammatory Bowel Disease[J]. Journal of Crohn's and Colitis, 2024, 18(Supplement_1): i374-i374.
- [3]. Kumar A, et al. 3-Aminobenzoic Acid Analogues as a Novel GABA-at Inhibitors: Synthesis, Pharmacological Evaluation and Molecular Docking Studies[J]. Drug Discovery and Development, 2014, 1(2): 110-120.
