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Cat. No.: HY-N21606

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Cascaroside A

Cascaroside A is a naturally occurring anthraquinone glycoside compound. Cascaroside A can be hydrolyzed to yield barbaloin, which upon reaction with ferric chloride produces Aloe emodin (HY-N0189). Cascaroside A serves as a marker compound for the quantitative determination of anthraquinone content in the bark extract of Rhamnus purshiana DC..

For research use only. We do not sell to patients.

CAS No.: 53823-08-8
Formula: C₂₇H₃₂O₁₄
Molecular Weight:580.53

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (288 KB)

Cascaroside A Chemical Structure

CAS No.: 53823-08-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

Cascaroside A is an anthraquinone C-glycoside derived from aloe-emodin and undergoes mild acid hydrolysis in N HCl at 70°C to release barbaloin^[1].
Cascaroside A can be quantified in freeze-dried and spray-dried Rhamnus purshiana bark extracts by HPLC-DAD at 293 nm^[2].
Cascaroside A as the main anthraquinone marker in Rhamnus purshiana bark extract exerts concentration-dependent phytotoxicity on Lactuca sativa seedlings, inhibiting root elongation and shoot growth; the extract induces mitotic inhibition and aneuploidy damage in seedling meristematic cells, with extracts containing higher Cascaroside A content exhibiting stronger cytotoxicity and genotoxicity, while also producing a biphasic effect on SOD activity and lipid peroxidation in seedlings^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 53823-08-8
Molecular Weight 580.53
Formula C₂₇H₃₂O₁₄
SMILES

O[C@H]1[C@](O[C@@H]([C@H]([C@@H]1O)O)CO)([H])[C@@]2([H])C3=CC=CC(O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO)=C3C(C5=C(O)C=C(CO)C=C52)=O
Structure Classification
- Flavonoids
- Isoflavones
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (288 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Fairbairn J W. Vegetable purgatives containing anthracene derivatives: Part VII. The evaluation of cascara sagrada and its preparations. Journal of Pharmacy and Pharmacology, 1953, 5(1): 827-838.

[2]. Souza K S, et al. Phytotoxicity and cytogenotoxic effects of extracts from the medicinal bark of Rhamnus purshiana DC. (Rhamnaceae). Journal of Toxicology and Environmental Health, Part A, 2025, 88(12): 505-517.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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