2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. RAR/RXR
  4. CD2665

CD2665 is an orally active and selective RAR-β,γ antagonist, with Kd values of 306 nM, 110 nM for RAR-β and RAR-γ, repectively.

For research use only. We do not sell to patients.

CD2665 Chemical Structure

CD2665 Chemical Structure

CAS No. : 170355-78-9

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 128 In-stock
Solution
10 mM * 1 mL in DMSO USD 128 In-stock
Solid
1 mg USD 50 In-stock
5 mg USD 120 In-stock
10 mg USD 200 In-stock
25 mg USD 420 In-stock
50 mg USD 695 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

CD2665 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

CD2665 is an orally active and selective RAR-β,γ antagonist, with Kd values of 306 nM, 110 nM for RAR-β and RAR-γ, repectively[1][3].

IC50 & Target

Ki: 110 nM (RARγ), 306 nM (RARβ)[1]
In Vitro

CD2665 (100 nM; 9 days; 3T3 cells) has significant effects on cell growth and differentiation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CD2665 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: 3T3 cells
Concentration: 100 nM
Incubation Time: 9 days
Result: Abrogated the antiprolferative effects of ATRA , CD271 (adapalene, an RAR-β,γ agonist), and CD2043 (RAR-α,β,γ pan-agonist) returning cell numbers and percent LFCS to control level.
In Vivo

CD2665 (0.6 mg/kg; Subcutaneous injection; daily, for 22 days) completely inhibits the overexpression of RARβ mRNA in the brain of alcohol treated mice[2].
CD2665 is a selective retinoid antagonist and elicits the expected maturation delay and growth plate expansion[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice submitted to 10 months of ethanol consumption[2].
Dosage: 0.6 mg/kg
Administration: Subcutaneous injection; daily, for 22 days.
Result: Decreased brain RARβ mRNA levels (50% relative to control), without any change in RXR β/γ mRNA levels.
Animal Model: Male and female mice (3 weeks)[3].
Dosage: 1.6 mg/kg
Administration: Oral gavage/intragastric; daily, for 31 days.
Result: Growth plate closure had largely been prevented in LDE225/antagonist co-treated mice compared with those receiving LDE225 only.
Molecular Weight

486.60

Formula

C31H34O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

COCCOCOC1=CC2=CC=C(C3=CC=C(C(O)=O)C=C3)C=C2C=C1C45C[C@H](C6)C[C@H](C[C@H]6C5)C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (128.44 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0551 mL 10.2754 mL 20.5508 mL
5 mM 0.4110 mL 2.0551 mL 4.1102 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C1

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Volume (start)

V1

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.91%

COA (248 KB) HNMR (280 KB) RP-HPLC (250 KB) MS (73 KB) Elemental Analysis Report (105 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0551 mL 10.2754 mL 20.5508 mL 51.3769 mL
5 mM 0.4110 mL 2.0551 mL 4.1102 mL 10.2754 mL
10 mM 0.2055 mL 1.0275 mL 2.0551 mL 5.1377 mL
15 mM 0.1370 mL 0.6850 mL 1.3701 mL 3.4251 mL
20 mM 0.1028 mL 0.5138 mL 1.0275 mL 2.5688 mL
25 mM 0.0822 mL 0.4110 mL 0.8220 mL 2.0551 mL
30 mM 0.0685 mL 0.3425 mL 0.6850 mL 1.7126 mL
40 mM 0.0514 mL 0.2569 mL 0.5138 mL 1.2844 mL
50 mM 0.0411 mL 0.2055 mL 0.4110 mL 1.0275 mL
60 mM 0.0343 mL 0.1713 mL 0.3425 mL 0.8563 mL
80 mM 0.0257 mL 0.1284 mL 0.2569 mL 0.6422 mL
100 mM 0.0206 mL 0.1028 mL 0.2055 mL 0.5138 mL
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CD2665 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CD2665170355-78-9CD 2665CD-2665RAR/RXRRetinoic acid receptorsRetinoid X receptorsRARβRARγRAR-αRAR-betaRAR-gammaInhibitorinhibitorinhibit

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