CDR3a23

CDR3a23 (L-pep) (40-800 nM; 4 h) specifically binds to CD38 on the surface of HL-60 cells, with a binding affinity higher than that of cyclic C-pep^[1].
CDR3a23 (L-pep) (100-2000 nM; 4 h) binds to CD38 on HL-60 cells with a K_d of 630 nM^[1].
CDR3a23 (L-pep) (800 nM; 3 days) exhibits a time-dependent antiproliferative effect on HL-60 cells, but not on SH-SY5Y cells^[1].
CDR3a23 (L-pep) (100-1000 nM; 48 h) inhibits HL-60 cell proliferation with an IC₅₀ of 540 nM, which decreases to 390 nM when combined with 1 μM Retinoic acid (ATRA) (HY-14649), while showing no effect on SH-SY5Y cells^[1].
CDR3a23 (L-pep) (540 nM; 48 h) induces 47.5% total apoptosis in HL-60 cells at its IC₅₀ concentration, and this proportion increases to 72.5% when combined with 1 μM ATRA^[1].
CDR3a23 (L-pep) (540 nM; 48 h) induces G1 phase arrest in 52.21% of HL-60 cells, and this proportion increases to 65.9% when combined with 1 μM ATRA^[1].
CDR3a23 peptide (100 ns) stably binds to the active site of human CD38 with a binding energy of -10.2 kcal/mol^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.