Celivarone
Celivarone (SSR149744C) is a orally active noniodinated benzofuran derivative with antiarrhythmic properties. Celivarone has the potential for atrial fibrillation and in ventricular arrhythmias research.
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- CAS. Nr.: 401925-43-7
- Formel: C34H47NO4
- Molecular Weight:533.74
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Celivarone (SSR149744C) exhibits electrophysiological and hemodynamic properties of class I, II, III, and IV antiarrhythmic agents[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
At the ventricular level, Celivarone (0.1-10 mg/kg IV and 3-90 mg/kg PO) prevents reperfusion-induced arrhythmias in anesthetized rats with a dose-effect relationship, and, at doses of 30 to 90 mg/kg PO, it reduced early (0-24 hours) mortality following permanent left coronary artery ligature in conscious rats[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 401925-43-7
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Molecular Weight 533.74
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Formel C34H47NO4
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SMILES
O=C(C1=CC2=C(OC(CCCC)=C2C(C3=CC=C(CCCN(CCCC)CCCC)C=C3)=O)C=C1)OC(C)C
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Synonyms
SSR149744C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Avinash R Khitri, et al. Celivarone for maintenance of sinus rhythm and conversion of atrial fibrillation/flutter. J Cardiovasc Electrophysiol. 2012 May;23(5):462-72. [Content Brief]
[2]. Patrick Gautier, et al. In vivo and in vitro antiarrhythmic effects of SSR149744C in animal models of atrial fibrillation and ventricular arrhythmias. J Cardiovasc Pharmacol. 2005 Feb;45(2):125-35. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Celivarone Related Classifications
HY-106207 Related Classifications
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