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United States

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Cat. No.: HY-162925

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CGRP antagonist 6

CGRP antagonist 6 (Compound 23) is a CGRP receptor antagonist (K_i: 0.84 nM). CGRP antagonist 6 can be used for research of migraine.

For research use only. We do not sell to patients.

Formula: C₂₉H₂₅F₃N₄O₃
Molecular Weight:534.53

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

CGRP antagonist 6 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

CGRP antagonist 6 (Compound 23) is a CGRP receptor antagonist (K_i: 0.84 nM). CGRP antagonist 6 can be used for research of migraine^[1].

Chemical Information

Molecular Weight 534.53
Formula C₂₉H₂₅F₃N₄O₃
SMILES

O=C1[C@@H](NC(C2=CC=C3C(C[C@@]4(C(C=CC=N5)=C5NC4=O)C3)=C2)=O)C[C@@H](C6=CC=CC=C6)CN1CC(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Staas DD, et al. Invention of novel 3-aminopiperidin-2-ones as calcitonin gene-related peptide receptor antagonists. Bioorg Med Chem Lett. 2024 Nov 1;112:129944. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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