Tiodazosin
Tiodazosin is a potent competitive postsynaptic alpha adrenergic receptor antagonist.
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- CAS. Nr.: 66969-81-1
- Formel: C18H21N7O4S
- Molecular Weight:431.47
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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- Reinheit & Dokumentation
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Help & FAQs
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Biologische Aktivität
Beschreibung
IC50 & Target
alpha adrenergic receptor[1]
In Vitro
Tiodazosin is a potent competitive postsynaptic alpha adrenergic receptor antagonist. In the mesenteric artery, Tiodazosin produces a parallel shift to the right in the concentration response curves to norepinephrine. A Schild plot constructed from two concentrations of Tiodazosin results in a pA2 value of 8.66 and a slope equal to -0.99. Tiodazosin inhibits contraction to norepinephrine in the portal vein and the inhibition results in a nonparallel inhibition of the norepinephrine concentration-response curve with a marked depression of maximal norepinephrine response[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 66969-81-1
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Molecular Weight 431.47
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Formel C18H21N7O4S
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SMILES
O=C(N1CCN(C2=NC(N)=C3C=C(OC)C(OC)=CC3=N2)CC1)C4=NN=C(SC)O4
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Synonyms
BL-5111
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
Cell Assay[1]
Arteries and portal veins isolated male Wistar rats (150 to 300 g) are sued and prepared for in vitro studies. Vessels are incubated with appropriate concentrations of Tiodazosin, prazosin or phentolamine for one hour. Contractile responses to norepinephrine or potassium chloride are then repeated in the presence of Tiodazosin[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Tiodazosin Related Classifications
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