ZD8321
ZD8321 is a potent inhibitor of human Neutrophil elastase (NE) with a Ki of 13±1.7 nM.
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- CAS. Nr.: 182073-77-4
- Formel: C18H28F3N3O5
- Molecular Weight:423.43
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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HY-17443
SivelestatElastase Inhibitor -
HY-15651
AlvelestatNeutrophil Elastase Inhibitor -
HY-75957
DMP 777Elastase Inhibitor -
HY-17443A
Sivelestat sodium -
HY-15891A
GW311616 hydrochlorideHNE Inhibitor -
HY-15891
GW311616HNE Inhibitor -
HY-17443R
Sivelestat (Standard)Elastase Inhibitor -
HY-15651R
Alvelestat (Standard)Reference Standard -
HY-17443B
Sivelestat sodium tetrahydrateNeutrophil Elastase Inhibitor -
HY-111457A
BAY-678 -
HY-15652
FreselestatNeutrophil Elastase Inhibitor -
HY-118177
Neutrophil elastase inhibitor 1Human Neutrophil Elastase Inhibitor
Biologische Aktivität
Beschreibung
IC50 & Target
Ki: 13±1.7 nM (Neutrophil elastase)[1]
In Vitro
TNFα-activated HUVEC is dose dependently inhibited by ZD8321.The adhesion between cancer cells with high elastase activity and TNFα-activated HUVEC is also inhibited by ZD8321. Expression of cell surface E-selectin by NE stimulation is suppressed in the presence of ZD8321. The concentration of soluble E-selectin in the medium increases after adhesive reaction between neutrophils and HUVEC. This increase is also dose dependently inhibited by ZD8321[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 182073-77-4
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Appearance Solid
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Molecular Weight 423.43
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Formel C18H28F3N3O5
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Color Light yellow to yellow
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SMILES
COC(N[C@@H](C(C)C)C(N1[C@@H](CCC1)C(N[C@@H](C(C)C)C(C(F)(F)F)=O)=O)=O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Reinheit & Dokumentation
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Veale CA, et al. Orally active trifluoromethyl ketone inhibitors of human leukocyte elastase. J Med Chem. 1997 Sep 26;40(20):3173-81. [Content Brief]
[2]. Nozawa F, et al. Elastase activity enhances the adhesion of neutrophil and cancer cells to vascular endothelial cells. J Surg Res. 2000 Dec;94(2):153-8. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
ZD8321 Related Classifications
HY-U00256 Related Classifications
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