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Art. -Nr.: HY-157548

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Antitumor agent-133

Antitumor agent-133 (compound 4d) is a bis-isatin derivative, with activities against Huh1 (IC₅₀=17.13 μM) and Huh7 (IC₅₀=8.27 μM). Antitumor agent-133 induces cell autophagy and inhibits tumor growth through regulation of LC3BII, ATG5 and p62 proteins.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₂₇H₂₄Br₂N₄O₈
Molecular Weight:692.31

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Antitumor agent-133 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
AML12	IC₅₀	>100 μM Compound: 4d	Antiproliferative activity against mouse AML12 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 method Antiproliferative activity against mouse AML12 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 method	[PMID: 38224754]
H22	IC₅₀	16.89 μM Compound: 4d	Antiproliferative activity against mouse H22 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 method Antiproliferative activity against mouse H22 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 method	[PMID: 38224754]
HepG2	IC₅₀	>100 μM Compound: 4d	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 method Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 method	[PMID: 38224754]
Huh-7	IC₅₀	8.27 μM Compound: 4d	Antiproliferative activity against human Huh-7 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 method Antiproliferative activity against human Huh-7 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 method	[PMID: 38224754]
MHCC97H	IC₅₀	>100 μM Compound: 4d	Antiproliferative activity against human MHCC97H cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 method Antiproliferative activity against human MHCC97H cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 method	[PMID: 38224754]

In Vitro

Antitumor agent-133 (0-100 μM, 48h) exhibits antitumor activities with IC₅₀ values of 17.13 μM (Huh1) and 8.27μM (Huh7) and selectivity towards cancer cells ^[1].
Antitumor agent-133 (0-100 μM, 48h) induces cancer cell autophagy through regulating the expressions of LC3B (I and II), ATG5 and p62^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Antitumor agent-133 (15 mg/kg, i.p., once every two days for 14 days) inhibits tumor growth in Xenograft model in NCG mice and exhibits low toxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Huh1 xenograft model in NCG mice ^[1]
Dosage:

i.p., 15 mg/kg, once every two days for 14 days
Administration:

intraperitoneal injection
Result:

Inhibited tumor growth.

Chemical Information

Molecular Weight 692.31
Formel C₂₇H₂₄Br₂N₄O₈
SMILES

COC([C@@H](NC(CN1C(C(C2=CC(Br)=CC=C21)=O)=O)=O)CCCCNC(CN3C(C(C4=CC(Br)=CC=C43)=O)=O)=O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Li Z, et al., Synthesis, biological activity evaluation and mechanism of action of novel bis-isatin derivatives as potential anti-liver cancer agents. Bioorg Med Chem Lett. 2024 Jan 13;99:129613. doi: 10.1016/j.bmcl.2024.129613 [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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