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Art. -Nr.: HY-162594

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Antitumor agent-164

Antitumor agent-164 (compound 60c) is a colchicine-binding site inhibitor (CBSI) with potency against taxane-sensitive TNBC. Antitumor agent-164 is a next-generation derivative of VERU-111.

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CAS. Nr.: 2757188-21-7
Formel: C₂₂H₂₀FNO₅
Molecular Weight:397.40

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (241 KB)

Antitumor agent-164 Chemical Structure

CAS. Nr.: 2757188-21-7

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Biologische Aktivität
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Chemical Information
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Biologische Aktivität

Beschreibung

Antitumor agent-164 (compound 60c) is a colchicine-binding site inhibitor (CBSI) with potency against taxane-sensitive TNBC. Antitumor agent-164 is a next-generation derivative of VERU-111^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	IC₅₀	1.8 nM Compound: 60c	Antiproliferative activity against human A-375 cells assessed as cell growth inhibition incubated for 72 hrs by MTS assay Antiproliferative activity against human A-375 cells assessed as cell growth inhibition incubated for 72 hrs by MTS assay	[PMID: 34378386]
A-375	IC₅₀	5.1 nM Compound: 60c	Cytotoxicity against human A-375 cells measured after 72 hrs by western blot Cytotoxicity against human A-375 cells measured after 72 hrs by western blot	[PMID: 34378386]
A375/TxR	IC₅₀	5.3 nM Compound: 60c	Cytotoxicity against paclitaxel resistant human A-375/TxR cells measured after 72 hrs by western blot Cytotoxicity against paclitaxel resistant human A-375/TxR cells measured after 72 hrs by western blot	[PMID: 34378386]
M14	IC₅₀	1.9 nM Compound: 60c	Antiproliferative activity against human M14 cells assessed as cell growth inhibition incubated for 72 hrs by MTS assay Antiproliferative activity against human M14 cells assessed as cell growth inhibition incubated for 72 hrs by MTS assay	[PMID: 34378386]
M14	IC₅₀	2.8 nM Compound: 60c	Cytotoxicity against human M14 cells measured after 72 hrs by western blot Cytotoxicity against human M14 cells measured after 72 hrs by western blot	[PMID: 34378386]
M14	IC₅₀	4.9 nM Compound: 60c	Cytotoxicity against paclitaxel resistant human M14 cells measured after 72 hrs by western blot Cytotoxicity against paclitaxel resistant human M14 cells measured after 72 hrs by western blot	[PMID: 34378386]
MDA-MB-231	IC₅₀	2.2 nM Compound: 60c	Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by MTS assay Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by MTS assay	[PMID: 34378386]
MDA-MB-231	IC₅₀	5.8 nM Compound: 60c	Cytotoxicity against human MDA-MB-231 cells measured after 72 hrs by western blot Cytotoxicity against human MDA-MB-231 cells measured after 72 hrs by western blot	[PMID: 34378386]
MDA-MB-453	IC₅₀	1.4 nM Compound: 60c	Antiproliferative activity against human MDA-MB-453 cells assessed as cell growth inhibition incubated for 72 hrs by MTS assay Antiproliferative activity against human MDA-MB-453 cells assessed as cell growth inhibition incubated for 72 hrs by MTS assay	[PMID: 34378386]
RPMI-7951	IC₅₀	2.4 nM Compound: 60c	Antiproliferative activity against human RPMI-7951 cells assessed as cell growth inhibition incubated for 72 hrs by MTS assay Antiproliferative activity against human RPMI-7951 cells assessed as cell growth inhibition incubated for 72 hrs by MTS assay	[PMID: 34378386]
SK-BR-3	IC₅₀	4.8 nM Compound: 60c	Antiproliferative activity against human SK-BR-3 cells assessed as cell growth inhibition incubated for 72 hrs by MTS assay Antiproliferative activity against human SK-BR-3 cells assessed as cell growth inhibition incubated for 72 hrs by MTS assay	[PMID: 34378386]

Chemical Information

CAS. Nr. 2757188-21-7
Molecular Weight 397.40
Formel C₂₂H₂₀FNO₅
SMILES

CC1=CC=C(C2=CC=C(F)C(C(C3=CC(OC)=C(OC)C(OC)=C3)=O)=N2)C=C1O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.