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Art. -Nr.: HY-176738

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Antitumor agent-204

Antitumor agent-204 (compound 15a) is a potent antitumor agent. Antitumor agent-204 shows cytotoxicity. Antitumor agent-204 induces nitric oxide (NO) release and reactive oxygen species (ROS) generation. Antitumor agent-204 induces apoptosis and induces cell cycle arrest at G2/M phase. Antitumor agent-204 shows antitumor activity.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₃₉H₃₃N₃O₈S
Molecular Weight:703.76

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (278 KB)

Antitumor agent-204 Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Antitumor agent-204 (compound 15a) (0-10 μM; 48 h) shows cytotosicity for A549, A549/Taxol MDA-MB-231, MCF-7, BEAS-2B, HUVEC cells with IC₅₀s of 4.43, 0.87, 1.20, 5.54, 10.73, 13.25 μM, respectively^[1].
Antitumor agent-204 (1, 2.5, 5 μM; 24 h) induces cell apoptosis in a dose-dependentmanner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

A549, A549/Taxol, MDA-MB-231, MCF-7, BEAS-2B, HUVEC cells
Concentration:

0-10 μM
Incubation Time:

48 h
Result:

Showed cytotoxicity for A549, A549/Taxol MDA-MB-231, MCF-7, BEAS-2B, HUVEC cells with IC₅₀s of 4.43, 0.87, 1.20, 5.54, 10.73, 13.25 μM, respectively.

Apoptosis Analysis^[1]

Cell Line:

A549/Taxol cells
Concentration:

1, 2.5, 5 μM
Incubation Time:

24 h
Result:

Induced cell apoptosis in a dose-dependentmanner.

In Vivo

Antitumor agent-204 (1, 5, 10 mg/kg; IP; once every 4 days for 16 days) shows antitumor activity in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Female BALB/c nude mice (A549/Taxol cells)^[1]
Dosage:

1, 5, 10 mg/kg
Administration:

IP; Once every 4 days for 16 days
Result:

Showed antitumor activity by significantly inhibited tumor growth by 50.2 %, 61.2 %, and 72.3 % (w/w) at 1, 5, and 10 mg/kg, respectively.

Chemical Information

Molecular Weight 703.76
Formel C₃₉H₃₃N₃O₈S
SMILES

CN1CCOC2=C3OC4=C1C=CC(CCC5=CC=C(C(OC6=CC=C(CCC3=CC=C2)C=C6)=C5)OC7=NO[N+]([O-])=C7S(=O)(C8=CC=CC=C8)=O)=C4
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Sun JY, et al. Discovery of hybrids of bisbibenzyl with furoxan as lysosomotropic agents for the treatment of drug-resistant non-small-cell lung cancer. Eur J Med Chem. 2025 Jun 15;296:117856. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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