Avosentan (Standard)

(Synonyms: Ro 67-0565 (Standard); SPP-301 (Standard))

Avosentan (Standard) is the analytical standard of Avosentan (HY-15195). This product is intended for research and analytical applications. Avosentan is an orally active endothelin (ETA) receptor antagonist. Avosentan can block the ETA receptor, thereby reducing vascular contraction, and exerting a renal protective effect. Avosentan inhibits vascular contraction caused by ET-1 and alleviates the reduction in retinal and optic nerve head blood flow induced by it, lowering intraocular pressure in the glaucoma monkey model. Avosentan non-specifically blocks ETB receptors at high doses, inhibiting ETB-mediated diuresis and natriuresis, and may cause fluid retention. Avosentan can be used to reduce proteinuria with diabetic nephropathy, but induces significant fluid overload and congestive heart failure.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

  • Reinheit : 98%
  • CAS. Nr.: 290815-26-8
  • Formel: C23H21N5O5S
  • Molecular Weight:479.51
  • Speicherung:

    Please store the product under the recommended conditions in the Certificate of Analysis.

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