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Barzolvolimab

(Synonyms: CDX-0159)
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Based on 1 Customer Validation

Barzolvolimab is a humanized anti-KIT IgG1 monoclonal antibody. Barzolvolimab specificity and potently inhibits KIT activation by SCF. Barzolvolimab can reduce skin mast cells and disease activity in chronic inducible urticaria.

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  • Reinheit: 99.00%
  • CAS. Nr.: 2438203-51-9
  • Molecular Weight:145.1 kDa
  • Speicherung:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Barzolvolimab
  • Experimental Validation Results for Barzolvolimab
  • Experimental Validation Results for Barzolvolimab
  • Experimental Validation Results for Barzolvolimab
  • Barzolvolimab Chemical Structure
    Barzolvolimab Chemical Structure
CAS. Nr.: 2438203-51-9
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Barzolvolimab Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Finden Sie Ihren Händler vor Ort Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Immobilized CD117/c-kit Protein, Human (HEK293, His, HY-P72752) can bind Barzolvolimab. The EC50 for this effect is 4.976 ng/mL.

  • 1/16

    Flow cytometric analysis of 1.5×106 THP-1 cells labeling Barzolvolimab (HY-P99462, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • 1/16

    Loaded Barzolvolimab on ProA biosensor, can bind CD117/c-kit Protein, Human (HEK293, His, HY-P72752) with an affinity constant of 1.128E-09 M as determined in BLI assay.

  • Barzolvolimab Chemical Structure
    1/16
  • Barzolvolimab
  • Immobilized CD117/c-kit Protein, Human (HEK293, His, HY-P72752) can bind Barzolvolimab. The EC50 for this effect is 4.976 ng/mL.
  • Flow cytometric analysis of 1.5×106 THP-1 cells labeling Barzolvolimab (HY-P99462, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • Loaded Barzolvolimab on ProA biosensor, can bind CD117/c-kit Protein, Human (HEK293, His, HY-P72752) with an affinity constant of 1.128E-09 M as determined in BLI assay.