Belapectin
Based on 1 Customer Validation
Belapectin (GR-MD-02) is a Galectin-3 (Gal-3) inhibitor. Belapectin drives tumor-induced immunosuppression by inducing T cell Apoptosis. Belapectin promotes tumor regression and improves survival of tumor-bearing mice through a CD8+ T cell-dependent mechanism. Belapectin binds to Gal-3 with affinity Ki of 2.8 μM.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.94%
- CAS. Nr.: 1980787-47-0
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
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Galectin-3 |
Belapectin (0.2 mg/mL, 2 mg/mL; 48 h) inhibits the proliferation of 4T1 and MCA-205 cells and induced apoptosis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:TRAMP-C1, 4T1 and MCA-205 cells
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Concentration:0.2 mg/mL, 2 mg/mL
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Incubation Time:48 h
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Result:Decreased the proliferation and resulted a minimal increase in apoptosis of 4T1 and MCA-205 cells. But showed no impact on TRAMP-C1 cell.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wild-type C57BL/6 and BALB/c mice[1]
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Dosage:2.4 mg/mouse, accompanied with anti-OX40 mAb (250 µg)
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Administration:Intraperitoneal injection; 3 times per week for 3 weeks
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Result:Inhibited tumor growth.
Enhanced the efficacy of checkpoint blockade (aPD-L1) immunotherapy.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 1980787-47-0
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Appearance Solid
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Color White to off-white
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SMILES
[Belapectin]
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Synonyms
GR-MD-02
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
H2O : 10 mg/mL (ultrasonic and warming and heat to 60°C)
Reinheit & Dokumentation
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Data Sheet (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Belapectin Related Classifications
HY-114440 Related Classifications
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