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Art. -Nr.: HY-120168

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CCG 258001

CCG 258001 is a GRK inhibitor with IC₅₀ values of 0.29, 51.8, and 33 µM against GRK2, GRK1, and GRK5, respectively. CCG 258001 inhibits GRK activity in cardiomyocytes and other muscle cells. CCG 258001 is applicable to the research of heart diseases, including heart failure, myocardial hypertrophy, and hypertension.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 2055990-96-8
Formel: C₂₀H₂₂FN₃O
Molecular Weight:339.41

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

CCG 258001 Chemical Structure

CAS. Nr.: 2055990-96-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

GRK2

0.29 μM (IC₅₀)

GRK5

33 μM (IC₅₀)

In Vitro

CCG 258001 (5 min) potently inhibits GRK2 with an IC₅₀ of 0.29 µM, while it shows weak inhibitory effects on GRK1 and GRK5^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2055990-96-8
Molecular Weight 339.41
Formel C₂₀H₂₂FN₃O
SMILES

C(OC=1C=C2C(=CC1)NN=C2)[C@H]3[C@@H](CCN(C)C3)C4=CC=C(F)C=C4
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Scott D. Larsen, et al. G protein-coupled receptor kinase inhibitors and methods for use of the same. WO2016210403A1. 2017-12-26

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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