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Art. -Nr.: HY-206735

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CDC14A/B-IN-2

CDC14A/B-IN-2, phosphotyrosine mimetic, is a competitive human CDC14A/B phosphatase inhibitor with IC₅₀ values of 10.4 and 11.2 μM, and K_i values of 5.8 and 7.3 μM. CDC14A/B-IN-2 shows at least 20-fold selectivity over other protein tyrosine phosphatases. CDC14A/B-IN-2 can be used for the research of cancer.

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CAS. Nr.: 3048654-21-0
Formel: C₁₃H₉F₂O₄P
Molecular Weight:298.18

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

CDC14A/B-IN-2 Chemical Structure

CAS. Nr.: 3048654-21-0

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

hCDC14A

10.4 μM (IC₅₀)

hCDC14B

11.2 μM (IC₅₀)

hCDC14A

5.8 μM (Ki)

hCDC14B

7.3 μM (Ki)

In Vitro

CDC14A/B-IN-2 (Compound 9) (10 min) competitively inhibits recombinant human CDC14A and CDC14B phosphatases with IC₅₀ values of 10.4 and 11.2 μM, and K_i values of 5.8 and 7.3 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 3048654-21-0
Molecular Weight 298.18
Formel C₁₃H₉F₂O₄P
SMILES

O=P(O)(C(F)(C1=C2C3=C(C=CC=C3)OC2=CC=C1)F)O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Dong J, et al. Development of Novel Phosphonodifluoromethyl-Containing Phosphotyrosine Mimetics and a First-In-Class, Potent, Selective, and Bioavailable Inhibitor of Human CDC14 Phosphatases. J Med Chem. 2024;67(11):8817-8835. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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