CHIR-29498
CHIR-29498 is an antibacterial peptoid. CHIR-29498 is active against both Gram-positive and Gram-negative bacteria. CHIR-29498 can be used for the study of fatal Staphylococcus aureus.
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- CAS. Nr.: 236102-25-3
- Formel: C38H55N5O3
- Molecular Weight:629.88
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
CHIR-29498 (0.6-40 μM, 18-24 h) is active against both Gram-positive and Gram-negative bacteria[1].
CHIR-29498 (20-40 μM) can continuously increase the extracellular β-galactosidase activity of Escherichia coli ML-35 (ATCC 43827), indicating cell membrane leakage[1].
CHIR-29498 (20-40 μM, 0.5-2 h) causes 54.4% (1× MIC) and 74.2% (2× MIC) of Staphylococcus aureus ATCC 25923 to be stained with PI after incubation for 30 minutes; after 2 hours, the staining percentages increased to 78.1% and 94.1%, respectively, indicating increased membrane permeability. The effect of DHAA is relatively weak[1].
CHIR-29498 (1 h) induces hemolysis in mice (BALB/c) or human erythrocytes (RBCs) at concentrations above the MIC, but the hemolytic activity is mild[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female CD-1 mice (weighing approximately 25 grams) were inoculated with approximately 108 CFU of bacteria via intraperitoneal injection[1].
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Dosage:3 mg/kg, 10 mg/kg, 30 mg/kg
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Administration:I.p., once
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Result:Protected 100% of the animals at a dose of 10 mg/kg.
Protected 50% of the animals when dosed (30 mg/kg) 110 min after i.p. infection.
Chemical Information
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CAS. Nr. 236102-25-3
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Molecular Weight 629.88
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Formel C38H55N5O3
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SMILES
O=C(N(CC(N)=O)C1CCCC2=C1C=CC=C2)CN(CCN)C(CNC[C@]3(C)CCC[C@]4(C)C5=C(CC[C@@]34[H])C=C(C(C)C)C=C5)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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