Cyanostatin B
Cyanostatin B, a cyanobacterial lipopeptide, is a leucine aminopeptidase M (LAP) inhibitor (IC50 = 12 ng/mL). Cyanostatin B is a weak inhibitor of protein phosphatase (PP2A) and also exhibits weak inhibitory activity against angiotensin-converting enzyme (ACE), with an IC50 value of 130 μg/mL. Cyanostatin B demonstrates both cytotoxic and genotoxic effects on human hepatocytes, although non-toxic to Artemia salina. Cyanostatin B inhibits the proliferation of HepG2 cells, induces DNA single-strand breaks, and causes genomic instability..
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- CAS. Nr.: 850131-23-6
- Formel: C40H59N5O9
- Molecular Weight:753.92
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Cyanostatin B (0-75 μg/mL, 24 h) exhibits no toxicity to juveniles (nauplii) of the brine shrimp[1].
Cyanostatin B (0-10 μg/mL, 24-48 h) exhibits concentration-dependent inhibition of cell proliferation after 72 hours of exposure in HepG2 cells[2].
Cyanostatin B (0-1 μg/mL, 24-48 h) induces DNA single-strand breaks (SSBs) but not DNA double-strand breaks (DSBs) in HepG2 cells[2].
Cyanostatin B (1 μg/mL, 24-72 h) is clastogenic, causing chromosome breakage or loss of entire chromosomes in HepG2 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 850131-23-6
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Molecular Weight 753.92
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Formel C40H59N5O9
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Sano T, et al. Leucine aminopeptidase M inhibitors, cyanostatin A and B, isolated from cyanobacterial water blooms in Scotland. Phytochemistry. 2005 Mar;66(5):543-8. [Content Brief]
[2]. Ujvárosi AZ, et al. The cyanobacterial oligopeptides microginins induce DNA damage in the human hepatocellular carcinoma (HepG2) cell line. Chemosphere. 2020 Feb;240:124880. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Cyanostatin B Related Classifications
HY-P11334 Related Classifications
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