DPPE-PEG2000-A7R

DPPE-PEG2000-A7R is composed of three covalently linked components: 1. DPPE (1,2-dipalmitoyl-sn-glycerol-3-phosphoethanolamine): Lipid anchoring group-inserts into the lipid bilayer of liposomes/LNPs, providing stable membrane anchoring; its saturated C16 chain imparts bilayer rigidity. 2. PEG 2000 (polyethylene glycol, molecular weight 2000): Hydrophilic polymer spacer arm-forms a steric hindrance crown around nanoparticles, reducing opsonin activity and reticuloendothelial system (RES) clearance, prolonging circulating half-life, and providing spatial separation between the lipid surface and the targeting ligand. 3. A7R peptide: Targeting/functional ligand-the A7R peptide (sequence ATWLPPR) binds with high affinity to neuropilin 1 (NRP-1), which is highly expressed on the surface of various tumor cells, competitively inhibiting the interaction between VEGF 165 and NRP-1, exhibiting anti-angiogenic activity.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.