EBOV-IN-1
Based on 1 publication(s) in Google Scholar
EBOV-IN-1 (com 3.47) is an adamantane dipeptide piperazine and an inhibitor of Ebola virus (EBOV). EBOV-IN-1 targets Niemann-Pick C1 (NPC1) and inhibits its binding to the EBOV glycoprotein (GP) that activates and mediates viral penetration into host cells, thereby inhibiting EBOV infection. EBOV-IN-1 inhibits pseudotyped EBOV infection with an IC50 of 13 nM.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 98.66%
- CAS. Nr.: 1335113-30-8
- Formel: C34H43N3O5
- Molecular Weight:573.72
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
- Protokoll
- Reinheit & Dokumentation
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Publications Citing Use of MedChemExpress (MCE) EBOV-IN-1
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Biologische Aktivität
Beschreibung
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero C1008 | IC50 |
13 nM
Compound: 3.47
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Antiviral activity against VSV pseudotyped Ebolavirus expressing M-GFP infected in African green monkey Vero E6 cells assessed as inhibition of viral infection pre-incubated for 2 hrs before infection and measured after 8 to 12 hrs by fluorescence microsc
Antiviral activity against VSV pseudotyped Ebolavirus expressing M-GFP infected in African green monkey Vero E6 cells assessed as inhibition of viral infection pre-incubated for 2 hrs before infection and measured after 8 to 12 hrs by fluorescence microsc
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[PMID: 29920098] |
| Vero C1008 | IC50 |
64 nM
Compound: 3.47
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Antiviral activity against recombinant VSV pseudotyped Ebolavirus expressing M-GFP infected in African green monkey Vero E6 cells assessed as inhibition of viral infection pre-incubated for 2 hrs before infection and measured after 8 to 12 hrs in presence
Antiviral activity against recombinant VSV pseudotyped Ebolavirus expressing M-GFP infected in African green monkey Vero E6 cells assessed as inhibition of viral infection pre-incubated for 2 hrs before infection and measured after 8 to 12 hrs in presence
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[PMID: 29920098] |
Chemical Information
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CAS. Nr. 1335113-30-8
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Appearance Solid
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Molecular Weight 573.72
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Formel C34H43N3O5
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Color White to off-white
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SMILES
COC(=O)C1=CC=C(COC2=CC=CC=C2CN2CCN(C(=O)CNC(=O)CC34CC5CC(CC(C5)C3)C4)CC2)C=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell
Molecular characterization of Ebola virus glycoprotein V75A substitution in the 2018-2020 epidemic. [Abstract]2026 Feb 5;189(3):818-831.e19. PMID: 41576953
Protokoll
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Reinheit & Dokumentation
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Data Sheet (269 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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