FLT3 ligand-2
Based on 1 Customer Validation
FLT3 ligand-2 is a Ligand for Target Protein for PROTAC. FLT3 ligand-2 can be used to synthesize PROTAC FLT-3 degrader 1 (HY-114323).
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- Reinheit : 98.05%
- CAS. Nr.: 950769-51-4
- Formel: C23H21N5O3S
- Molecular Weight:447.51
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
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FLT-3 |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MV4-11 | IC50 |
0.15 nM
Compound: 6b
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Antiproliferative activity against human MV4-11 cells after 72 hrs by cell titer-blue cell viability assay
Antiproliferative activity against human MV4-11 cells after 72 hrs by cell titer-blue cell viability assay
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[PMID: 19754199] |
Chemical Information
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CAS. Nr. 950769-51-4
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Appearance Solid
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Molecular Weight 447.51
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Formel C23H21N5O3S
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Color White to off-white
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SMILES
OC1=CC2=C(N3C(S2)=NC(C4=CC=C(NC(NC5=NOC(C(C)(C)C)=C5)=O)C=C4)=C3)C=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 50 mg/mL (111.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.2346 mL | 11.1729 mL | 22.3459 mL | 55.8647 mL |
| 5 mM | 0.4469 mL | 2.2346 mL | 4.4692 mL | 11.1729 mL | |
| 10 mM | 0.2235 mL | 1.1173 mL | 2.2346 mL | 5.5865 mL | |
| 15 mM | 0.1490 mL | 0.7449 mL | 1.4897 mL | 3.7243 mL | |
| 20 mM | 0.1117 mL | 0.5586 mL | 1.1173 mL | 2.7932 mL | |
| 25 mM | 0.0894 mL | 0.4469 mL | 0.8938 mL | 2.2346 mL | |
| 30 mM | 0.0745 mL | 0.3724 mL | 0.7449 mL | 1.8622 mL | |
| 40 mM | 0.0559 mL | 0.2793 mL | 0.5586 mL | 1.3966 mL | |
| 50 mM | 0.0447 mL | 0.2235 mL | 0.4469 mL | 1.1173 mL | |
| 60 mM | 0.0372 mL | 0.1862 mL | 0.3724 mL | 0.9311 mL | |
| 80 mM | 0.0279 mL | 0.1397 mL | 0.2793 mL | 0.6983 mL | |
| 100 mM | 0.0223 mL | 0.1117 mL | 0.2235 mL | 0.5586 mL |
FLT3 ligand-2 Related Classifications
HY-168702 Related Classifications
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