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Art. -Nr.: HY-19284

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FR-146687

(Synonyms: FK 687; TF 505)

FR-146687 (FK 687) is a selective and orally active 5α-reductase inhibitor with IC₅₀s of 1.7 nM and 4.6 nM for rat and human 5α-reductases, respectively. FR-146687 shows no inhibitory effects on other steroid oxidoreductases.

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CAS. Nr.: 146939-64-2
Formel: C₃₃H₃₇NO₄
Molecular Weight:511.65

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

FR-146687 Chemical Structure

CAS. Nr.: 146939-64-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

IC50: 1.7 nM (Rat 5α-reductase) and 4.6 nM (Human 5α-reductase)^[1]

In Vivo

FR-146687 (0.032-3.2 mg/kg; po; 2, 7, 14, or 21 days) dose-dependently reduces ventral prostate and seminal vesicle weight at doses above 0.1 mg/kg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

4-week-old immature castrated male rats injected with Testosterone propionate (TP)^[1]
Dosage:

0.032 mg/kg, 0.32 mg/kg, 3.2 mg/kg
Administration:

po; 2, 7, 14, or 21 days
Result:

Dose-dependently reduced ventral prostate and seminal vesicle weight at doses above 0.1 mg/kg.

Chemical Information

CAS. Nr. 146939-64-2
Molecular Weight 511.65
Formel C₃₃H₃₇NO₄
SMILES

O=C(O)CCCC1=CC(C(C2=CC=C(O[C@H](C3=CC=C(CC(C)C)C=C3)CCC)C=C2)=O)=C4C=CC=CN14
Synonyms

FK 687; TF 505
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. O Nakayama, et al. FR146687, a novel steroid 5 alpha-reductase inhibitor: in vitro and in vivo effects on prostates. Prostate. 1997 Jun 1;31(4):241-9. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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