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Art. -Nr.: HY-181169

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GAK-IN-3

GAK-IN-3 is a cyclin G-associated kinase (GAK) inhibitor with an IC₅₀ of 207 nM and a K_i of 66 nM. GAK-IN-3 inhibits kinase activity in the nanomolar range by binding to GAK’s ATP-binding site. GAK-IN-3 acts as a cytotoxic agent that reduces viability of Ewing sarcoma cells. GAK-IN-3 can be used for the research of ewing sarcoma.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₁₉H₁₉N₅S
Molecular Weight:349.45

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

GAK-IN-3 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

GAK

207 nM (IC₅₀)

GAK

66 nM (Ki)

In Vitro

GAK-IN-3 (compound 3c) (10 μM; 48 h) reduces RD‐ES cell viability to 25.7% and Daoy cell viability to 44.6%^[1].
GAK-IN-3 (compound 3c) (0.225-7.2 μM; 48 h) inhibits RD‐ES cell viability with an IC₅₀ of 1.1 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

RD‐ES (Ewing Sarcoma), Daoy (medulloblastoma)
Concentration:

10 μM
Incubation Time:

48 h
Result:

Reduced RD‐ES cell viability to 25.7% and Daoy cell viability to 44.6% at 10 μM after 48 h incubation.

Cell Viability Assay^[1]

Cell Line:

RD‐ES
Concentration:

7.2, 3.6, 1.8,
0.9, 0.45, and 0.225 μM
Incubation Time:

48 h
Result:

Inhibited RD‐ES cell viability with an IC₅₀ of 1.1 μM after 48 h incubation.

Chemical Information

Molecular Weight 349.45
Formel C₁₉H₁₉N₅S
SMILES

S=C(N)N/N=C/C1=CC=NC2=CC=C(NC3=CC(C)=CC(C)=C3)C=C21
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Gentz CB, et al. New Quinoline Kinase Inhibitors With Good Selectivity for NAK Kinases and Anti-Tumor Activity Against Ewing Sarcoma. Arch Pharm (Weinheim). 2026;359(1):e70184. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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