Ilk - integrin linked kinase Gene

Also Known as ILK-1; ILK-2; ESTM24; p59ILK

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16202

Summary

Predicted to enable several functions, including SH3 domain binding activity; Integrin binding activity; and protein kinase binding activity. Involved in outflow tract morphogenesis; positive regulation of BMP signaling pathway; and positive regulation of osteoblast differentiation. Acts upstream of or within several processes, including fibroblast migration; nervous system development; and protein kinase B signaling. Located in focal adhesion and lamellipodium. Is expressed in several structures, including adipose tissue; alimentary system; brain; genitourinary system; and retina. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in pancreatic Cancer. Orthologous to human ILK (Integrin linked kinase). [provided by Alliance of Genome Resources, Apr 2022]

Ilk Products (2)

mRNA Protein Name
NM_001161724.1 NP_001155196.1 integrin-linked protein kinase
NM_010562.2 NP_034692.2 integrin-linked protein kinase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
10574708 MGI
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within Schwann cell development IMP
IMP: Inferred from mutant phenotype
19349584 MGI
acts upstream of or within branching involved in ureteric bud morphogenesis IDA
IDA: Inferred from direct assay
15831470 MGI
involved in caveola assembly IMP
IMP: Inferred from mutant phenotype
20951348 MGI
acts upstream of cell population proliferation IMP
IMP: Inferred from mutant phenotype
12835312 MGI
acts upstream of or within cell projection organization IMP
IMP: Inferred from mutant phenotype
19349584 MGI
acts upstream of or within establishment or maintenance of epithelial cell apical/basal polarity IMP
IMP: Inferred from mutant phenotype
12670870 MGI
acts upstream of or within fibroblast migration IMP
IMP: Inferred from mutant phenotype
23658024 MGI
acts upstream of or within myelination in peripheral nervous system IMP
IMP: Inferred from mutant phenotype
19349584 MGI
acts upstream of or within negative regulation of neural precursor cell proliferation IGI
IGI: Inferred from genetic interaction
24719101 MGI
acts upstream of or within negative regulation of neural precursor cell proliferation IMP
IMP: Inferred from mutant phenotype
24719101 MGI
acts upstream of or within nerve development IMP
IMP: Inferred from mutant phenotype
19349584 MGI
acts upstream of neural precursor cell proliferation IGI
IGI: Inferred from genetic interaction
24719101 MGI
acts upstream of neural precursor cell proliferation IMP
IMP: Inferred from mutant phenotype
24719101 MGI
involved in outflow tract morphogenesis IMP
IMP: Inferred from mutant phenotype
24131868 MGI
acts upstream of or within peptidyl-serine phosphorylation IMP
IMP: Inferred from mutant phenotype
19349584 MGI
acts upstream of or within phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
19349584 MGI
involved in positive regulation of BMP signaling pathway IMP
IMP: Inferred from mutant phenotype
20675382 MGI
acts upstream of or within positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
12835312 MGI
involved in positive regulation of osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
20675382 MGI
involved in protein localization to cell cortex IMP
IMP: Inferred from mutant phenotype
20951348 MGI
Cellular Component GO Annotation Evidence Verweise Source
located in focal adhesion IDA
IDA: Inferred from direct assay
12432066 MGI
located in lamellipodium IDA
IDA: Inferred from direct assay
18325335 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

integrin-linked protein kinase

  • 59 kDa serine/threonine-protein kinase

  • beta-integrin-linked kinase

  • integrin binding protein kinase

Ilk Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Cross
Ilk O55222 LIMS1 Homo sapiens P48059
Anti Tag CoIP
12432066
Cross
Ilk O55222 LIMS1 Homo sapiens P48059
ELISA
10574708
Intra
Ilk O55222 Parva Mus musculus Q9EPC1
Anti Bait CoIP
19798050
Intra
Ilk O55222 Parva Mus musculus Q9EPC1
Pull Down
19829382
Intra
Ilk O55222 Parva Mus musculus Q9EPC1
Anti Tag CoIP
23612611
Intra
Ilk O55222 Parva Mus musculus Q9EPC1
Anti Tag CoIP
19829382
Intra
Ilk O55222 Parvb Mus musculus Q9ES46
Anti Tag CoIP
23612611
Intra
Ilk O55222 Parvb Mus musculus Q9ES46
Anti Tag CoIP
19829382
Intra
Ilk O55222 Parvb Mus musculus Q9ES46
Anti Bait CoIP
19798050
Intra
Ilk O55222 Stub1 Mus musculus Q9WUD1
Anti Tag CoIP
23612611
Intra
Ilk O55222 Stub1 Mus musculus Q9WUD1
Fluorescence
23612611
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (11)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-113439 12-HETE Inhibitor 95.70% Unkown
HY-18676 OSU-T315 99.88% Unkown
HY-115677 ILK-IN-3 Inhibitor 99.62% Unkown
HY-18676B ILK-IN-2 99.41% Unkown
HY-113439S 12-HETE-d8 Inhibitor 98.03% Unkown
HY-P4866 Q-Peptide 99.46% Unkown
HY-177912 ILK-IN-4 Inhibitor / Unkown
HY-184113 Dihydropelitinib / Unkown
HY-RS06787 ILK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16756 Ilk Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23195 Ilk Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ilk NCBI NCBI:3611