Prx - periaxin Gene

Also Known as L-Periaxin

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19153

Summary

Involved in several processes, including myelination in peripheral nervous system; regulation of RNA splicing; and transmission of nerve impulse. Located in cytosol; nuclear speck; and plasma membrane. Is expressed in sciatic nerve. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 3 and Charcot-Marie-Tooth disease type 4F. Orthologous to human PRX (periaxin). [provided by Alliance of Genome Resources, Apr 2022]

Prx Products (2)

mRNA Protein Name
NM_019412.2 NP_062285.1 periaxin isoform S
NM_198048.2 NP_932165.2 periaxin isoform L

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
11430802 MGI
Biological Process GO Annotation Evidence Verweise Source
involved in peripheral nervous system myelin formation IMP
IMP: Inferred from mutant phenotype
10839370 MGI
involved in peripheral nervous system myelin maintenance IMP
IMP: Inferred from mutant phenotype
10839370 MGI
involved in regulation of RNA splicing IDA
IDA: Inferred from direct assay
21940993 MGI
involved in sensory perception of pain IMP
IMP: Inferred from mutant phenotype
10839370 MGI
involved in transmission of nerve impulse IMP
IMP: Inferred from mutant phenotype
10839370 MGI
Cellular Component GO Annotation Evidence Verweise Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15282162 MGI
located in cytosol IDA
IDA: Inferred from direct assay
9488714 MGI
located in nuclear speck IDA
IDA: Inferred from direct assay
21940993 MGI
located in nucleus IDA
IDA: Inferred from direct assay
15282162 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
9488714 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

periaxin

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (5)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-14848 Naluzotan 98.05% Phase 3
HY-15472 PRX-08066 97.46% Phase 2
HY-106385 PRX-03140 Agonist / Phase 2
HY-14559 PRX-07034 hydrochloride Antagonist 98.97% Phase 1
HY-100171A PRX933 Agonist / Phase 1
Inhibitory Antibodies (4)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-P99405 Prasinezumab Inhibitor 99.90% Phase 3
HY-P99554 Topsalysin / Phase 3
HY-P990708 Bizaxofusp / Phase 2
HY-P99543 Tulinercept Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (11)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-14848A Naluzotan hydrochloride 99.63% Unkown
HY-100171 PRX933 hydrochloride Agonist / Unkown
HY-15472A PRX-08066 maleate / Unkown
HY-158198 PRXS571 Modulator / Unkown
HY-19846 VRX-03011 Agonist / Unkown
HY-RS11079 PRDX6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11265 PRX Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W671129 Frenolicin B Inhibitor / Unkown
HY-177477 2,5-Epidithia-3,6-dioxopiperazine / Unkown
HY-RS17938 Prx Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24409 Prx Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-P991704 Moponetug Inhibitor 98.83% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prx NCBI NCBI:57716