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APLP1 - amyloid beta precursor like protein 1 Gene

Also Known as APLP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 333

About APLP1

Cytogenetic location: 19q13.12 Genomic coordinates (GRCh38): 19:35,868,574-35,879,792 (from NCBI)

This gene has 12 transcripts (splice variants), 187 orthologues and 2 paralogues. Biased expression in brain (RPKM 172.7) and adrenal (RPKM 17.0).

Summary

This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

APLP1 Products (2)

mRNA	Protein	Name
NM_001024807.3	NP_001019978.1	amyloid beta precursor like protein 1 isoform 1 precursor
NM_005166.5	NP_005157.1	amyloid beta precursor like protein 1 isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables alpha-2A adrenergic receptor binding	IPI IPI: Inferred from physical interaction	16531006	GOA
enables alpha-2B adrenergic receptor binding	IPI IPI: Inferred from physical interaction	16531006	GOA
enables alpha-2C adrenergic receptor binding	IPI IPI: Inferred from physical interaction	16531006	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16193067	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16169070	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in cellular response to norepinephrine stimulus	IDA IDA: Inferred from direct assay	16531006	GOA
involved in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	16531006	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	16531006	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	16531006	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

APLP1 Protein Structure

APP_N

APP_Cu_bd

APP_E2

APP_amyloid

0
100
200
300
400
500
600
651 a.a.

Protein Preferred Names	Protein Names
amyloid beta precursor like protein 1	amyloid beta (A4) precursor-like protein 1

APLP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	APLP1	P51693	APP	Homo sapiens	P05067-4	Anti Tag CoIP	16193067
Intra	APLP1	P51693	MED12	Homo sapiens	Q93074	Pull Down	21293490
Intra	APLP1	P51693	ZNF24	Homo sapiens	P17028	Anti Tag CoIP	16169070
Intra	APLP1	P51693	Tom1	Mus musculus	O88746	Anti Tag CoIP	14563850
Intra	APLP1	P51693	CNTN4	Homo sapiens	Q8IWV2	Pull Down	18272596
Intra	APLP1	P51693	APLP1	Homo sapiens	P51693	Anti Tag CoIP	16193067
Intra	APLP1	P51693	APLP1	Homo sapiens	P51693	X-Ray Diffraction	21930949
Intra	APLP1	P51693	CNTN5	Homo sapiens	O94779	Pull Down	18272596
Intra	APLP1	P51693	APLP2	Homo sapiens	Q06481	Anti Tag CoIP	16193067
Intra	APLP1	P51693	TSC22D1	Homo sapiens	Q15714	Y2H	21900206
Intra	APLP1	P51693	Slc5a7	Mus musculus	Q8BGY9	Anti Bait CoIP	17709753
Intra	APLP1	P51693	APLP1	Homo sapiens	P51693	Anti Bait CoIP	16193067

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant APLP1 Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P7502	APLP-1 Protein, Human (HEK293, His)	P51693 (G42-P212)	≥ 80%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Brain Compression	Compression Of Brain

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS00826	APLP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22393	Aplp1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28917	Aplp1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	APLP1	VGNC	VGNC:67755
Bos taurus	APLP1	VGNC	VGNC:26019
Mus musculus	APLP1	MGD	MGI:88046
Rattus norvegicus	APLP1	RGD	RGD:69257
Canis familiaris	APLP1	VGNC	VGNC:37988
Macaca mulatta	APLP1	VGNC	VGNC:69983
Others	APLP1	NCBI