APLP-1 Protein, Human (HEK293, His)
Based on 1 Customer Validation
APLP-1 Protein, Human (HEK293, His), also known as APLP1, is increased in the frontal cortex of Mn-exposed models.
- Species: Human
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- References
- Help & FAQs
Biological Activity
Description
APLP-1 Protein, Human (HEK293, His), also known as APLP1, is increased in the frontal cortex of Mn-exposed models.
Background
Human APLP-1 gene has been mapped to the long arm of chromosome 19 in the same region containing a late-onset familial AD locus. APLP1 is a member of the amyloid precursor family. Increased APLP1 expression and revealed the presence of amyloid-β diffuse plaques.
Technical Parameters
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Species Human
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Source HEK293
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Tag C-6*His
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Accession
P51693 (G42-P212)
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Molecular Construction
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N-term
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APLP-1 (G42-P212)
Accession # P51693 -
6*His
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C-term
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Protein Length
Partial Extracellular Domain
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Synonyms
APLP1; Amyloid-Like Protein 1; Amyloid Beta Precursor Like Protein 1; Amyloid Precursor-Like Protein 1; APLP; CDNA FLJ56046, Highly Similar To Amyloid-Like Protein 1 (APLP)(APLP-1); Amyloid Beta (A4) Precursor-Like Protein 1; APLP-1
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AA Sequence
GGSPGAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPP
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Predicted Molecular Mass
19.8 kDa
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Molecular Weight
Approximately 18-20 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 80%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
Lyophilized after extensive dialysis against PBS, 1 mM EDTA, pH 7.4.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
References
[1]. Guilarte TR, et al. APLP1, Alzheimer's-like pathology and neurodegeneration in the frontal cortex of manganese-exposed non-human primates. Neurotoxicology. 2010 Sep;31(5):572-4. [Content Brief]
[2]. Guilarte TR, et al. Increased APLP1 expression and neurodegeneration in the frontal cortex of manganese-exposed non-human primates. J Neurochem. 2008 Jun;105(5):1948-59. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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