APLP-1 Protein, Human (HEK293, His)

APLP-1 Protein, Human (HEK293, His), also known as APLP1, is increased in the frontal cortex of Mn-exposed models.

Human APLP-1 gene has been mapped to the long arm of chromosome 19 in the same region containing a late-onset familial AD locus. APLP1 is a member of the amyloid precursor family. Increased APLP1 expression and revealed the presence of amyloid-β diffuse plaques.

Human

HEK293

C-6*His

P51693 (G42-P212)

333  [NCBI]

Partial

GGSPGAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPP

Approximately 18-20 kDa,based on SDS-PAGE under reducing conditions.

≥ 80%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.

• [1]. Guilarte TR, et al. APLP1, Alzheimer's-like pathology and neurodegeneration in the frontal cortex of manganese-exposed non-human primates. Neurotoxicology. 2010 Sep;31(5):572-4.  [Content Brief]

  [2]. Guilarte TR, et al. Increased APLP1 expression and neurodegeneration in the frontal cortex of manganese-exposed non-human primates. J Neurochem. 2008 Jun;105(5):1948-59.  [Content Brief]