2. Gene
  3. APLP1 - amyloid beta precursor like protein 1 Gene

APLP1 - amyloid beta precursor like protein 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as APLP

Gene ID: 333 | Gene type: protein coding

About APLP1

Cytogenetic location: 19q13.12 Genomic coordinates (GRCh38): 19:35,868,574-35,879,792 (from NCBI)

This gene has 12 transcripts (splice variants), 187 orthologues and 2 paralogues. Biased expression in brain (RPKM 172.7) and adrenal (RPKM 17.0).

Summary

This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

APLP1 Products(2)

mRNA Protein Name
NM_001024807.3 NP_001019978.1 amyloid beta precursor like protein 1 isoform 1 precursor
NM_005166.5 NP_005157.1 amyloid beta precursor like protein 1 isoform 2 precursor

APLP1 Protein Structure

APP_N

APP_N: Amyloid A4 N-terminal heparin-binding (54 - 154)

APP_Cu_bd

APP_Cu_bd: Copper-binding of amyloid precursor, CuBD (155 - 212)

APP_E2

APP_E2: E2 domain of amyloid precursor protein (284 - 467)

APP_amyloid

APP_amyloid: beta-amyloid precursor protein C-terminus (596 - 648)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 651 a.a.
Protein Preferred Names Protein Names

amyloid beta precursor like protein 1

amyloid beta (A4) precursor-like protein 1

Recombinant APLP1 Proteins

Cat. No. Product Name Accession Purity
HY-P7502 APLP-1 Protein, Human (171a.a, HEK293, His) P51693 (G42-P212) ≥95%
HY-P75510 APLP-1 Protein, Human (580a.a, HEK293, His) P51693 (M1-E580) ≥95%

Related Diseases

Diseases Alias
Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers
Brain Compression

Compression Of Brain
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00826 APLP1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus APLP1 VGNC VGNC:67755
Bos taurus APLP1 VGNC VGNC:26019
Mus musculus APLP1 MGD MGI:88046
Rattus norvegicus APLP1 RGD RGD:69257
Canis familiaris APLP1 VGNC VGNC:37988
Macaca mulatta APLP1 VGNC VGNC:69983