TLR8 - toll like receptor 8 Gene

Also Known as CD288; IMD98; hTLR8

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51311

About TLR8

Cytogenetic location: Xp22.2 Genomic coordinates (GRCh38): X:12,906,620-12,923,169 (from NCBI)

This gene has 2 transcripts (splice variants), 199 orthologues, 22 paralogues and is associated with 1 phenotype. Biased expression in appendix (RPKM 10.8), spleen (RPKM 6.1) and 9 other tissues.

Summary

The protein encoded by this gene is a member of the Toll-like Receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by RefSeq, Jul 2008]

TLR8 Products (2)

mRNA	Protein	Name
NM_138636.5	NP_619542.1	toll-like receptor 8 isoform 2 precursor
NM_016610.4	NP_057694.2	toll-like receptor 8 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables DNA binding	IDA IDA: Inferred from direct assay	16123302	GOA
enables double-stranded RNA binding	IDA IDA: Inferred from direct assay	16111635	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	23520111	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22164301	GOA
enables single-stranded RNA binding	IDA IDA: Inferred from direct assay	14976262	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	19593445	GOA
involved in defense response to virus	IDA IDA: Inferred from direct assay	33718825	GOA
involved in defense response to virus	IEP IEP: Inferred from expression pattern	32634389	GOA
involved in defense response to virus	IMP IMP: Inferred from mutant phenotype	16188996	GOA
involved in negative regulation of interleukin-12 production	IDA IDA: Inferred from direct assay	24942581	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	12032557	GOA
involved in positive regulation of innate immune response	IDA IDA: Inferred from direct assay	16123302	GOA
involved in positive regulation of interferon-alpha production	IDA IDA: Inferred from direct assay	16286015	GOA
involved in positive regulation of interferon-beta production	IDA IDA: Inferred from direct assay	16286015	GOA
involved in positive regulation of interleukin-1 beta production	IDA IDA: Inferred from direct assay	24942581	GOA
involved in positive regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	24942581	GOA
involved in positive regulation of interleukin-8 production	IMP IMP: Inferred from mutant phenotype	16188996	GOA
involved in positive regulation of type II interferon production	IDA IDA: Inferred from direct assay	16286015	GOA
involved in response to virus	IDA IDA: Inferred from direct assay	12032557	GOA
involved in toll-like receptor 8 signaling pathway	IDA IDA: Inferred from direct assay	12032557	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	24942581	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TLR8 Protein Structure

LRR_8

LRR_6

LRR_8

TIR

0
200
400
600
800
1041 a.a.

Protein Preferred Names	Protein Names
toll-like receptor 8

TLR8 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	TLR8	Q9NR97	UNC93B1	Homo sapiens	Q9H1C4	Anti Tag CoIP	22164301
Intra	TLR8	Q9NR97	UNC93B1	Homo sapiens	Q9H1C4	Anti Tag CoIP	33961781
Intra	TLR8	Q9NR97	UNC93B1	Homo sapiens	Q9H1C4	IF	22164301

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TLR8 Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P72270	Toll-like receptor 8/TLR8 Protein, Human (P.pastoris, His)	Q9NR97 (E27-T827)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Anemia, Autoimmune Hemolytic	Autoimmune Hemolytic Anemia Idiopathic Autoimmune Hemolytic Anemia Immuno-Hemolytic Anemia Anemia, Hemolytic, Autoimmune Autoimmune Haemolytic Anaemia Autoimmune Hemolytic Anaemia Acquired Autoimmune Hemolytic Anemia Anemia Hemolytic Autoimmune Familial Auto-Immune Hemolytic Anemia Aha Aiha
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Agammaglobulinemia	Hypogammaglobulinemia Ighm Mu Heavy Chain Deficiency Mu-Heavy Chain Disease Mu-Hcd Mu-Chain Disease
Anogenital Venereal Wart	Genital Warts Condylomata Acuminata Anogenital Warts Condyloma Acuminatum Anogenital Human Papilloma Virus Infectious Disease Genital Wart Virus Infectious Disease Venereal Wart Venereal Warts Verrucae Anogenitales Verrucae Genitales
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Immunodeficiency 98 With Autoinflammation, X-Linked	Infltr8 IMD98 Inflammation, Neutropenia, Bone Marrow Failure, And Lymphoproliferation Caused By Tlr8
Basal Cell Carcinoma	Basal Cell Cancer Basal Cell Neoplasm Basal Cell Carcinoma Of Skin Malignant Basal Cell Tumor Basal Cell Tumor Epithelioma Basal Cell Malignant Basal Cell Neoplasm Rodent Ulcer Carcinoma Basal Cell Neoplasms, Basal Cell Basal Cell Carcinomas Experimental Organism Basal Cell Carcinoma Nodulo-Ulcerative Basal Cell Carcinoma Basalioma Basal Cell Epithelioma Of Skin Bcc - [Basal Cell Carcinoma] Of Skin Rodent Ulcer Of Skin Rodent Ulcer Of Unspecified Site Basal Cell Epithelioma Of Unspecified Site
Superficial Basal Cell Carcinoma	Multifocal Superficial Basal Cell Carcinoma Multicentric Basal Cell Carcinoma Superficial Multicentric Basal-Cell Carcinoma
Aicardi-Goutieres Syndrome	Aicardi Goutieres Syndrome Cree Encephalitis Encephalopathy With Basal Ganglia Calcification Aicardi-Goutières Syndrome Ags Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid Pseudotoxoplasmosis Syndrome Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis Aicardi-Goutieres Syndrome 1
Spherocytosis, Type 5	Hereditary Spherocytosis Type 5 SPH5 Hs5 Spherocytosis, Hereditary, 5 Hereditary Spherocytosis 5 Spherocytosis 5 Spherocytosis, Hereditary, Type 5
X-Linked Immunodeficiency 74	Immunodeficiency 74, Covid-19-Related, X-Linked Imd74 Respiratory Insufficiency Due To Sars-Cov-2 Viral Infection Tlr7 Deficiency X-Linked Immunodeficiency 74,Covid-19-Related
Viral Infectious Disease	Arbovirus Infections Viral Disease Virus Infection Virus Diseases Viral Infection Viral Infections Virus Infections
Actinic Keratosis	Solar Keratosis Actinic Keratosis Senile Hyperkeratosis Sk - Solar Keratosis Keratosis, Actinic Seborrheic Keratosis Ak - [Actinic Keratosis] Sk - [Solar Keratosis]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (8)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-134581A	Enpatoran hydrochloride	Inhibitor	99.42%	Phase 3
HY-13740	Resiquimod	Agonist	99.95%	Phase 2
HY-13773	Motolimod	Agonist	98.10%	Phase 2
HY-109137	Selgantolimod	Agonist	98.18%	Phase 2
HY-13740G	Resiquimod (GMP)	Agonist	/	Phase 2
HY-177617A	Bazlitoran sodium	Agonist	95.30%	Phase 2
HY-177617	Bazlitoran	Agonist	95.30%	Phase 2
HY-109104	Telratolimod	Agonist	98.85%	Phase 1

Pre-clinical Phase

Bioactive Molecules (56)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-134581	Enpatoran	Inhibitor	99.87%	Unkown
HY-128799	CL097	Agonist	99.90%	Unkown
HY-160229	ssRNA40 sodium	Activator	98.34%	Unkown
HY-20457	TL8-506	Agonist	95.0%	Unkown
HY-103697	Gardiquimod		99.91%	Unkown
HY-103698	TLR7/8 agonist 1	Agonist	98.42%	Unkown
HY-112667	CU-CPT-9a	Antagonist	99.74%	Unkown
HY-139323	TLR7/8-IN-1	Inhibitor	99.92%	Unkown
HY-103698A	TLR7/8 agonist 1 dihydrochloride	Agonist	99.70%	Unkown
HY-117066	CL075	Agonist	99.18%	Unkown
HY-112050	CU-CPT-8m	Antagonist	99.98%	Unkown
HY-128799A	CL097 hydrochloride	Agonist	99.96%	Unkown
HY-101929	CU-CPT17e	Agonist	98.67%	Unkown
HY-130797	TLR7/8 agonist 3	Agonist	99.96%	Unkown
HY-153879	C12-TLRa	Ligand	99.71%	Unkown
HY-159102	PVP-037.2	Agonist	99.18%	Unkown
HY-13740S	Resiquimod-d5	Agonist	98.33%	Unkown
HY-139017	TLR7/8 agonist 4	Agonist	99.18%	Unkown
HY-138139B	AXC-715 trihydrochloride	Agonist	99.76%	Unkown
HY-131945	CU-115	Antagonist	99.63%	Unkown
HY-103697A	Gardiquimod diTFA		99.0%	Unkown
HY-138139A	AXC-715 hydrochloride	Agonist	99.89%	Unkown
HY-112051	CU-CPT9b	Antagonist	99.03%	Unkown
HY-145885	TLR7/8 agonist 6	Agonist	98.93%	Unkown
HY-176774	L07-2	Agonist	99.83%	Unkown
HY-145960A	MC-Val-Cit-PAB-Amide-TLR7 agonist 4 formic	Agonist	97.70%	Unkown
HY-164485	INI-4001	Activator	/	Unkown
HY-145960	MC-Val-Cit-PAB-Amide-TLR7 agonist 4	Agonist	99.39%	Unkown
HY-178037	TLR9 antagonist 1	Antagonist	/	Unkown
HY-153543	TLR7/8 agonist 8	Agonist	98.69%	Unkown
HY-10018	Toll-like receptor modulator	Modulator	99.36%	Unkown
HY-139017A	TLR7/8 agonist 4 TFA	Agonist	/	Unkown
HY-141454	TLR8 agonist 2	Agonist	/	Unkown
HY-141454A	TLR8 agonist 2 hydrochloride	Agonist	/	Unkown
HY-145886	TLR7/8 antagonist 1	Antagonist	/	Unkown
HY-175782	SMU-R39	Antagonist	/	Unkown
HY-183276	TLR8 antagonist-2	Antagonist	/	Unkown
HY-121496	3M-011	Agonist	/	Unkown
HY-161630	TLR8 agonist 8	Agonist	/	Unkown
HY-162845	TLR7/8 agonist 11	Agonist	/	Unkown
HY-161629	TLR8 agonist 7	Agonist	/	Unkown
HY-161631	TLR8 agonist 9	Agonist	/	Unkown
HY-163670	TLR7 agonist 21	Inhibitor	/	Unkown
HY-169057	BI1543673	Inhibitor	/	Unkown
HY-153544	TLR7/8 agonist 9	Inhibitor	/	Unkown
HY-160228A	ORN 02 sodium	Activator	/	Unkown
HY-159916	AYK004	Agonist	/	Unkown
HY-176553	KBD4466	Inhibitor	/	Unkown
HY-179209	TLR9-IN-2	Inhibitor	/	Unkown
HY-160228	ORN 02	Activator	/	Unkown
HY-20457G	TL8-506 (GMP)	Agonist	/	Unkown
HY-179336	TLR7/8 agonist 14	Agonist	/	Unkown
HY-179047	SMU-L11-R	Agonist	/	Unkown
HY-177300	TLR7/8 agonist 13	Agonist	/	Unkown
HY-181841	TLR8 agonist 10	Agonist	/	Unkown
HY-159919	UM-3006	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TLR8	RGD	RGD:1590327
Macaca mulatta	TLR8	VGNC	VGNC:78391
Canis familiaris	TLR8	VGNC	VGNC:55002
Mus musculus	TLR8	MGD	MGI:2176887
Felis catus	TLR8	VGNC	VGNC:66221
Others	TLR8	NCBI