L07-2
Based on 1 Customer Validation
L07-2 is a TLR7/8 agonist. L07-2 is a linker-toxin building block that can be used to synthesize immunostimulatory antibody conjugates (ISACs) for cancer research. L07-2 can be used to studies related to tumors such as non-small cell lung cancer.
For research use only. We do not sell to patients.
- Purity: 99.83%
- CAS No.: 3093296-36-4
- Formula: C56H83N15O14
- Molecular Weight:1190.35
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Storage:
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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TLR7 |
TLR8 |
L07-2 (compound 6) (6 h) acts as a potent TLR7/8 dual agonist that activates NF-κB signaling in H-TLR7 and H-TLR8 reporter 293 cells, with stronger TLR7 activity than Resiquimod (R848)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3093296-36-4
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Appearance Solid
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Molecular Weight 1190.35
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Formula C56H83N15O14
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Color White to off-white
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SMILES
O=C(C=C1)N(CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N[C@@H](CC(C)(C)C)C(NCCOC(C)(C)CN2C(COCC)=NC3=C2C4=C(C=CC=C4)N=C3N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C1=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
DMSO : ≥ 100 mg/mL (84.01 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.8401 mL | 4.2004 mL | 8.4009 mL | 21.0022 mL |
| 5 mM | 0.1680 mL | 0.8401 mL | 1.6802 mL | 4.2004 mL | |
| 10 mM | 0.0840 mL | 0.4200 mL | 0.8401 mL | 2.1002 mL | |
| 15 mM | 0.0560 mL | 0.2800 mL | 0.5601 mL | 1.4001 mL | |
| 20 mM | 0.0420 mL | 0.2100 mL | 0.4200 mL | 1.0501 mL | |
| 25 mM | 0.0336 mL | 0.1680 mL | 0.3360 mL | 0.8401 mL | |
| 30 mM | 0.0280 mL | 0.1400 mL | 0.2800 mL | 0.7001 mL | |
| 40 mM | 0.0210 mL | 0.1050 mL | 0.2100 mL | 0.5251 mL | |
| 50 mM | 0.0168 mL | 0.0840 mL | 0.1680 mL | 0.4200 mL | |
| 60 mM | 0.0140 mL | 0.0700 mL | 0.1400 mL | 0.3500 mL | |
| 80 mM | 0.0105 mL | 0.0525 mL | 0.1050 mL | 0.2625 mL |
L07-2 Related Classifications
HY-176774 Related Classifications
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