POU2F2 - POU class 2 homeobox 2 Gene

Also Known as OCT2; OTF2; Oct-2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5452

About POU2F2

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:42,086,110-42,197,936 (from NCBI)

This gene has 21 transcripts (splice variants), 261 orthologues and 17 paralogues. Broad expression in lymph node (RPKM 11.8), spleen (RPKM 7.4) and 14 other tissues.

Summary

The protein encoded by this gene is a homeobox-containing transcription factor of the POU domain family. The encoded protein binds the octamer sequence 5'-ATTTGCAT-3', a common transcription factor binding site in immunoglobulin gene promoters. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

POU2F2 Products (10)

mRNA	Protein	Name
NM_001207025.4	NP_001193954.1	POU domain, class 2, transcription factor 2 isoform 1
NM_001207026.3	NP_001193955.1	POU domain, class 2, transcription factor 2 isoform 3
NM_001247994.3	NP_001234923.1	POU domain, class 2, transcription factor 2 isoform 4
NM_001393934.1	NP_001380863.1	POU domain, class 2, transcription factor 2 isoform 5
NM_001393935.1	NP_001380864.1	POU domain, class 2, transcription factor 2 isoform 6
NM_001393936.1	NP_001380865.1	POU domain, class 2, transcription factor 2 isoform 7
NM_001394376.1	NP_001381305.1	POU domain, class 2, transcription factor 2 isoform 8
NM_001394377.1	NP_001381306.1	POU domain, class 2, transcription factor 2 isoform 9
NM_001394378.1	NP_001381307.1	POU domain, class 2, transcription factor 2 isoform 10
NM_002698.6	NP_002689.1	POU domain, class 2, transcription factor 2 isoform 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	9242494	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in nucleus	IDA IDA: Inferred from direct assay	9242494	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POU2F2 Protein Structure

Pou

Homeobox

0
100
200
300
400
479 a.a.

Protein Preferred Names	Protein Names
POU domain, class 2, transcription factor 2	homeobox protein

POU2F2 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P81782	Oct-2 Antibody (YA1527)	WB, ICC/IF, FC, IP	Human, Mouse, Rat
HY-P85672	OCT1 Antibody (YA5364)	WB, IHC-P, ICC/IF,	Human
HY-P85923	Oct-2 Antibody (YA5615)	IHC-P, WB, ICC/IF, ELISA	Human, Mouse,
HY-P86025	Oct-2 Antibody (YA5717)	IHC-P, ELISA	Human, Mouse,
HY-P86308	Oct-2 Antibody (YA6000)	WB, IHC-P, ICC/IF, IP, ELISA	Human

Related Diseases

Diseases	Alias
B-Cell Lymphoma	Lymphoma, B-Cell B-Cell Lymphomas B-Cell Lymphocytic Neoplasm Lymphoma B-Cell B-Cell Lymphoma Nos
Papilloma	Papillomatosis
Prion Disease	Spongiform Encephalopathy Transmissible Spongiform Encephalopathies Prion Diseases Prion Disease Pathway Transmissible Spongiform Encephalopathy Prion Induced Disorder Prion Protein Disease Inherited Human Transmissible Spongiform Encephalopathies Prion Protein Diseases Prion-Associated Disorders Prion-Induced Disorders Transmissible Dementias Tses Human Prion Disease Tse Encephalopathy, Transmissible Spongiform Prion Disease, Susceptibility To Spongiform Encephalopathies Human Transmissible Spongiform Encephalopathies, Inherited
Arthrogryposis, Distal, Type 1a	Distal Arthrogryposis Type 1 Digitotalar Dysmorphism DA1A Da1 Amcd1 Arthrogryposis, Distal, Type 2b4 Distal Arthrogryposis Type 1a Arthrogryposis, Distal, Type 1 Arthrogryposis Multiplex Congenita Distal Type 1 Arthrogryposis Multiplex Congenita, Distal Type 1 Arthrogryposis Multiplex Congenita, Distal, Type I Distal Arthrogryposis Type 1b Arthrogryposis, Distal, 1a Amc Arthrogryposis Multiplex Congenita Arthrogryposis, Distal, 2b4 DA2B4 Arthrogryposis Multiplex Congenita, Distal, Type 1 Arthrogryposis
Lymphoma, Hodgkin, Classic	Hodgkin Lymphoma Hodgkin Disease Hodgkin'S Lymphoma Hodgkins Lymphoma Classic Hodgkin Lymphoma CHL Hodgkin Lymphoma, Susceptibility To Hl Hodgkin'S Sarcoma Stage I Subdiaphragmatic Hodgkin Lymphoma Stage Ii Subdiaphragmatic Hodgkin Lymphoma Lymphoma, Hodgkin'S Classic Hodgkin Disease Hodgkin'S Disease Lymphoma, Hodgkin, Susceptibility To Hodgkin'S Disease Of Intrapelvic Lymph Nodes Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb Malignant Lymphogranuloma Malignant Lymphogranulomatosis Malignant Hodgkin Lymphoma Classical Hodgkin Lymphoma, Type Not Specified

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS10898	POU2F2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20583	Pou2f2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27091	Pou2f2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	POU2F2	VGNC	VGNC:59358
Rattus norvegicus	POU2F2	RGD	RGD:621690
Felis catus	POU2F2	VGNC	VGNC:68965
Mus musculus	POU2F2	MGD	MGI:101897
Canis familiaris	POU2F2	VGNC	VGNC:44827
Others	POU2F2	NCBI